Dharambir K Sanghera

Contact Information:
Dharambir K Sanghera



 

Sanghera, Dharambir (HSC)
Faculty

Department of:

College Of Medicine/Peds - Genetics -Associate Professor

Center of:

OK Center for Neurosciences -Member

Education:

Fellowship: Genetic Epidemiology, Graduate School of Public Health, University of Pittsburgh, PA     1995
Fellowship: Molecular Mutagenesis, Graduate School of Public Health, University of Pittsburgh, PA     1993
Human Genetics, Guru Nanak Dev University, Amritsar, India   Ph.D.   1992

Professional Interest/Expertise/Specializations:
RESEARCH INTERESTS: Diabetes, Cardiovascular disease, Obesity, Genetics, and Genomics. Dr. Sanghera's research specializes in the study of molecular and genetic epidemiological aspects of common complex diseases including non-insulin dependent diabetes mellitus (T2D), coronary heart disease, hypertension, and metabolic syndrome. Common traits with complex inheritance have both genetic and environmental causes. Her laboratory is focused on efforts to understand the interplay between environmental and genetic factors involved in T2D and coronary heart disease pathogenesis. Rising epidemic of cardiometabolic diseases is a growing public health problem among the immigrant populations in the US, particularly in the ethnicities that have migrated from rural areas to westernized urban environments. The reasons underlying these conditions are not understood. The aim of Dr. Sanghera's research is to identify genetic susceptibility underlying T2D, insulin resistance, obesity, and dyslipidemia using a South Asian cohort of Punjabi origin from Northern India and the US Asian Indians who are first generation immigrants and residents of states of Oklahoma, Texas, and California. Asian Indians have high predisposition for developing central obesity associated with metabolic and cardiovascular diseases when exposed to western diet and obesogenic environment. The long-term goals of Dr. Sanghera's research are; 1) to identify the underlying molecular mechanisms associated with these disorders, 2) to improve the classification of the disease process by identifying genome-wide patterns associated with ethnic variation, and 3) to discover new gene-based targets based on ethnic origin and environmental and cultural differences which can inform the design of early prevention and treatment therapy among immigrant populations.

Websites:

Deparment of Pediatrics

Research Projects:

Selected Publications:

Genetic variation in cholesterol ester transfer protein (CETP), serum CETP activity, and coronary artery disease risk in Asian Indian diabetic cohort.
2011    Schierer A, Been LF, Ralhan S, Wander GS, Aston, CE, Sanghera DK
Pharmacogenet Genomics Epub doi: 10.1097/FPC.0b013e32834dc9ef.
Association of genetic variation in FTO with risk of obesity and type 2 diabetes in up to 96,551 East and South Asians.
2011    Liu C, Kilpelainen T, Li H, Zhu J, Liu Y, Hu C, Yang Z, Bao W, Cha S, Wu Y, Yang T, Sekine A, Choi BY, Yajnik CS, Zhou D, Ikegami H, Chan J, Mani KR, Been LF, Imamura M, Yokota M, Lee N, Takayanagi R, Karasawa S, Wen W, Lu W, Chang YC, Xiang Y, Gao Y, Liu S, Song Y, Park KS, Kwak SH, Shin HD, Fall C, Kim JY, Lam KSL, Zheng W, Shu XO, Deng H, Nakashima E, Sanghera DK, Chuang LM, Liu L, Hu R, Kim Y
Diabetologia. doi 10.1007/s00125-011-2370-7
Genome-wide association study in people of South Asian ancestry identifies five novel susceptibility loci for type 2 diabetes.
2011    Kooner JS, Saleheen D, Sim X, Frossard P, Zhang W, Sehmi J, Been LF, Dimas AS, Hassanali N, Jafar T, Jowett JBM, Venkatesan R, Rees SD, Takeuchi F, Aung T, Basit A, Chidambaram M, Das D, Grunberg E, Hedman AK, Hydrie ZI, Islam M, Kowlessur S, Kristensen MM, Liju S, Matthews DR, Morris AP, Nica AC, Pinidiyapathirage JM, Prokopenko I, Rasheed A, Samuel M, Seielstad M, Shah N, Shera AS, Sma
Nat Genet doi:10.1038/ng.921.
Genome-wide linkage scan to identify loci associated with type 2 diabetes and blood lipid phenotypes in the Sikh Diabetes Study.
2011    Sanghera DK, Been LF, Ralhan S, Wander GS, Mehra NK, Singh JR, Ferrell RE, Kamboh MI, Aston CE
PLoS One 6(6): doi:10.1371/journal.pone.0021188.
Variants in KCNQ1 increase type 2 diabetes susceptibility in South Asians: A study of 3,310 Asian Indians from India and the US.
2011    Been LF, Ralhan S, Wander GS, Mehra NK, Singh JR, Mulvihill JJ, Sanghera DK.
BMC Med Genet 12: 18.
Association of variants within the FTO and MC4R genes with obesity-related traits and type 2 diabetes in Pakistani populations.
2011    Rees SD, Hydrie MZI, Bellary S, O┬┐Hare JP, Kumar S, Sanghera DK, Shera AS, Barnett AH, Basit A, Kelly MA
Diabetic Med Epub doi: 10.1111/j.1464-5491.2011.03257.x.
). A novel variant near melatonin receptor-1B gene contributes to increased fasting glucose concentrations: Genetic risk is modulated by obesity status.
2011    Been LF, Hatfield JL, Shankar A, Aston CE, Ralhan S, Wander GS, Mehra NK, Singh JR, Mulvihill JJ, Sanghera DK
Nutr Metab Cardiovasc Dis Epub doi:10.1016/j.numecd.2011.01.006.
Novel polymorphisms in PPARG1, PPARG2, and ADIPOQ genes increase type 2 diabetes risk in Asian Indian Sikhs.
2010    Sanghera DK, Demirci Y, Been LF, Ortega L, Ralhan S, Wander GS, Mehra NK, Singh JR, Mulvihill JJ, Kamboh MI
Metab Clin Exp 59(4): 492:501
Replication of association between a common variant near melanocortin-4 receptor gene and obesity-related traits in a Sikh population from Northern India.
2010    Been LF, Nath SK, Ralhan SK, Wander GS, Mehra NK, Singh JR, Mulvihill JJ, Sanghera DK
Obesity 18(2):425:42
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