Anne Kasus-Jacobi

Contact Information:
Anne Kasus-Jacobi



 

Kasus-Jacobi, Anne (HSC)
Assistant Professor of Research

Department of:

College Of Pharmacy/Pharmaceutical Sciences -Assistant Professor of Research

Center of:

OK Center for Neurosciences -

Education:

University of Paris XI, France.   PhD, Endogrinology   1998
University of Paris VII. France   M.S., Cell Biology   1993
University of Paris VII. France   B.S., Cell Biology   1992

Professional Interest/Expertise/Specializations:
I am intrigued by the multiple functions of the imidazole-containing peptide derivatives, such as carcinine. I am particularly interested by their aldehyde-quenching effect since it can mimic the detoxification role of the photoreceptor inner segment RDHs. I have made the observation that carcinine can reach high levels in the retina after topical administration through eye drops. This, combined with the strong neuroprotective effect of carcinine, offers therapeutic potentials for progressive retinopathies that involve oxidative damage in their pathogenesis.

Websites:

Research Projects:

Oklahoma Health Research Program, OCAST. "Therapeutic use of carcinine in progressive retinopathy."
Identification of Membrane Receptor(s) for CAP37 and CAP37-derived Chemotactic Peptides. (COP seed grant)
Wound Healing Mechanisms Modulated by Novel Antimicrobial Peptides (OCAST)

Selected Publications:

A Multifunctional Peptide Based on the Neutrophil Immune Defense Molecule, CAP37, Has Antibacterial and Wound Healing Properties
2015    Kasus-Jacobi A, Griffith GL, Noor-Mahammadi S, Logan S, Hinsley H, Brevetti J, Mathias L, Pereira HA
J Leukoc Biol
The Antimicrobial Protein, CAP37, is Upregulated in Pyramidal Neurons during Alzheimer's Disease
2015    Brock AJ, Kasus-Jacobi A, Lerner M, Logan S, Adesina AM, Pereira HA
Histochem & Cell Biologoy
A Multifunctional peptide based on the neutrophil immune defense molecule, CAP37, has antibacterial and wound healing properties.
2014    Kasus-Jacobi A, Noor-Mohammadi S, Griffith GL, Hinsley H, Mathias L and Pereira HA
The Journal of Leukocyte Biology
Corneal Wound Healing, a Newly Identified Function of CAP37, Is Mediated by Protein Kinase C Delta (PKCdelta)
2014    Griffith GL, Kasus-Jacobi A, Lerner MR, Pereira HA
Invest Ophthalmol vis Sci. "Studies on Corneal and Lens Disorders" from the Springer series "Oxidative Stress in Applied Basic Research and Clinical Practice". Edited by Drs. Babizhayev, Allo, Li, Zoric and Kasus-Jacobi
CAP37 activation of PKC promotes human corneal epithelial cell chemotaxis.
2013    1. Griffith GL, Russell RA, Kasus-Jacobi A, Thavathiru E, Gonzalez ML, Logan S, Pereira HA.
Invest Ophthalmol Vis Sci. Sep 5. 2013 [Epub ahead of print] PMID: 24008408
Carcinine has 4-hydroxynonenal scavenging property and neuroprotective effect in mouse retina.
2012    Marchette LD, Wang H, Li F, Babizhayev MA, Kasus-Jacobi A.
Invest Ophthalmol Vis Sci. June 2012; 53(7):3572-83. PMID: 22577078
Novel intraocular and systemic absorption drug delivery and efficacy of N-acetylcarnosine lubricant eye drops or carcinine biologics in pharmaceutical usage and therapeutic vision care.
2012    Babizhayev MA, Khoroshilova-Maslova IP, Kasus-Jacobi A.
Fundam Clin Pharmacol. 2012 Oct; 26(5): 644-78. Epub 2011 Jul 27. PMID: 21793899
Alpha-phenyl-N-tert-butylnitrone (PBN) prevents light-induced degeneration of the retina by inhibiting RPE65 protein isomerohydrolase activity.
2011    Mandal MN, Moiseyev GP, Elliott MH, Kasus-Jacobi A, Li X, Chen H, Zheng L, Nikolaeva O, Floyd RA, Ma JX, Anderson RE.
J Biol Chem. 2011 Sep 16; 286(37):32491-501. Epub 2011 Jul 24. PMID: 21785167.
Retinol dehydrogenase 12 detoxifies 4-hydroxynonenal in photoreceptor cells.
2010    Marchette LD, Thompson DA, Kravtsova M, Ngansop TN, Mandal NA, Kasus-Jacobi A.
Free Radic Biol Med. 2010 Jan 1; 48(1):16-25. PMID: 19686838. PMC2874966.
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