Qing Guo

Contact Information:
Qing Guo



 

Guo, Qing (HSC)
Faculty

Department of:

College Of Medicine/Physiology -Professor of Physiology

Center of:

Education:

Hebei Medical University   M.D.   1984
The Third Military Medical University   M.S.   1987
Beijing PLA General Hospital   Ph.D.   1993

Professional Interest/Expertise/Specializations:
Current research in Dr. Guo's laboratory centers on some of the fundamental questions in the life and death of cells in a variety of organ systems and diseases. First, we examine how specific genetic mutations and cell death proteins regulate intracellular pathways that control neuronal life and death associated with neurodegenerative diseases. In this respect, we are specifically looking at the pathogenic mechanisms of presenilin-1 (PS-1) mutations and pro-apoptotic actions of prostate apoptosis response-4 (Par-4) protein in several transgenic mouse models of Alzheimer's disease (AD) and amyotrophic lateral sclerosis (ALS). Work in Dr. Guo's lab has contributed to our understanding of a number of mechanisms for dementia of Alzheimer's type caused by the heritable alterations of genetic information in presenilin proteins, which included the investigation of neuronal cell death process in the first mouse "knock-in" model of a naturally occurring presenilin-1 mutation responsible for an early-onset form of Alzheimer disease. Secondly, we are looking at how aberrant regulation of the apoptotic machinery is involved in pathological conditions outside the central nervous system, such as acute renal failure induced by ischemia/reperfusion. One of the factors we are currently working on is apoptosis antagonizing transcription factor (AATF), a novel leucine zipper protein that counteracts Par-4 activity in many physiological and pathological settings. Our studies involve the application of a variety of gene transfer, targeting and expression techniques, including those in applied in vitro in cultured cells and in vivo in transgenic and/or knockin mouse models. The overall goal of our research is to understand the molecular and cellular mechanisms of cell death in human diseases, and to identify novel therapeutic strategies using genetic and/or pharmacological manipulations.

Websites:

The web site provides additional information on Dr. Guo's work at OUHSC.

Research Projects:

Cellular and Molecular Mechanisms of Neurodegeneration
Anti-apoptotic Mechanisms in Renoprotection

Selected Publications:

New Evidence Links Calcium-Regulated Activation of Mitochondrial AGC1 to Autism.
2010    Qing Guo
Cell Science Reviews
Regulation of intracellular calcium in cortical neurons transgenic for human Abeta40 and Abeta42 following nutritive challenge.
2009    Najeeb A Shiwany, Jun Xie, and Qing Guo
Int J Clin Exp Med
Cortical neurons transgenic for human Aß40 or Aß42 have similar vulnerability to apoptosis despite their different amyloidogenic properties.
2009    Najeeb A Shiwany, Jun Xie, and Qing Guo
Int J Clin Exp Pathol
Exacerbation of apoptosis of cortical neurons following traumatic brain injury in Par-4 transgenic mice.
2008    Daniel J. Payette, Jun Xie, Najeeb Shirwany, and Qing Guo
Int J Clin Exp Pathol
Par-4 is Novel Mediator of Renal Tubule Cell Death in Models of Ischemia-Reperfusion Injury.
2007    Jun Xie and Qing Guo
Am. J. Physiol. Renal Physiol.
Defects of Immune Regulation in the Presenilin-1 Mutant Knock-in Mouse.
2007    Grant A. Morgan, Qing Guo, Sic L. Chan, Devin S. Gary, Barbara A. Osborne, and Mark P. Mattson
Neuromolecular Med.
Apoptosis Antagonizing Transcription Factor Protects Renal Tubule Cells against Oxidative Damage and Apoptosis Induced by Ischemia-Reperfusion.
2006    Jun Xie and Qing Guo
J. Am. Soc. Nephrol.
Par-4 Is involved in regulation of beta -secretase cleavage of the Alzheimer¿s amyloid precursor protein.
2005    Jun Xie and Qing Guo.
J Biol Chem.
RNAi knockdown of Par-4 inhibits neurosynaptic degeneration in ALS-linked mice.
2005    Jun Xie, Keytam S. Awad, and Qing Guo
J Neurochem.
Par-4 inhibits choline uptake by interacting with CHT1 and reducing its incorporation on the plasma membrane.
2004    Jun Xie and Qing Guo.
J Biol Chem
AATF inhibits aberrant production of amyloid beta peptide 1-42 by interacting directly with Par-4.
2004    Qing Guo and Xie, J.
J Biol Chem
Neurotrophic factors (ADNF and bFGF) interrupt excitotoxic neurodegenerative cascades promoted by a PS1 mutation.
1999    Qing Guo, Lois Sebastian, Bryce Sopher, Miles W. Miller, Gordon W. Glazner, Carol B. Ware, George M. Martin, and Mark P. Mattson
Proc. Natl. Acad. Sci. USA.
Increased vulnerability of hippocampal neurons to excitotoxic necrosis in presenilin-1 mutant knock-in mice.
1999    Qing Guo, Weiming Fu, Bryce Sopher, Miles W. Miller, Carol B. Ware, George M. Martin, and Mark P. Mattson
Nature Medicine
Calbindin D28K Blocks the Pro-Apoptotic Actions of Mutant Presenilin-1: Reduced Oxidative Stress and Preserved Mitochondrial Function.
1998    Qing Guo, Sylvia Christakos, Nic Robinson and Mark P. Mattson
Proc. Natl. Acad. Sci. USA.
Par-4 is a new mediator of neuronal degeneration associated with the pathogenesis of Alzheimer¿s disease.
1998    Qing Guo, Weiming Fu, Jun Xie, Hong Luo, Stephen J. Sells, James W. Geddes, Vimala Bondada, Vivek M. Rangnekar and Mark P. Mattson
Nature Medicine
Secreted beta-amyloid precursor protein counteracts the pro-apoptotic action of mutant presenilin-1 by activation of NF-kB and stabilization of calcium homeostasis.
1998    Qing Guo, Nic Robinson, and Mark P. Mattson
J. Biol. Chem.
Increased sensitivity to mitochondrial toxin-induced apoptosis in neural cells expressing mutant presenilin-1 in linked to perturbed calcium homeostasis and enhanced oxyradical production.
1998    Jeffrey N. Keller, Qing Guo, F.W. Holtsberg, A.J. Bruce-Keller, and Mark P. Mattson
J. Neurosci.
Alzheimer's PS-1 mutation sensitizes neural cells to apoptosis induced by trophic factor withdrawal and amyloid ¿-peptide: Involvement of calcium and oxyradicals.
1997    Qing Guo, Bryce L. Sopher, Katsutoshi Furukawa, Dao G. Pham, George M. Martin, and Mark P. Mattson
J. Neurosci.
Presenilins, the endoplasmic reticulum, and neuronal apoptosis in Alzheimer¿s disease.
1997    Mark P. Mattson, Qing Guo, Katsutoshi Furukawa, and Ward Peterson
J Neurochem.
Nerve growth factor-independent reduction in choline acetyltransferase activity in PC12 cells expressing mutant presenilin-1.
1997    Ward A. Peterson, Qing Guo, Boyd K. Hartmans, and Mark P. Mattson
J. Biol. Chem.