Youngjae You

Contact Information:
Youngjae You



 

You, Youngjae (HSC)
Associate Professor

Department of:

College Of Pharmacy/Pharmaceutical Sciences -Assistant Professor

Center of:

Education:

Chungnam National University, Taejon, Korea   Ph.D. (Medicinal Chemistry)   2001

Professional Interest/Expertise/Specializations:
Photodynamic therapy (PDT) is an emerging tool for treating cancers that is selective and causes minimum side effects compared to current standard treatment options such as surgery, radiotherapy, and chemotherapy. In PDT, the damage on tumor occurs from the combination of a small molecule (photosensitizer, PS), oxygen, and the light of near IR range (650-800 nm). We are interested in developing new PSs which overcome problems of current photosensitizers. The first goal is to develop new photosensitizers absorbing long-weave length (>750 nm) with high extinction coefficient. The second goal is to achieve higher selectivity toward cancer cells/tumor tissue over surrounding normal cells/tissues. To this end, unique characteristics of cancer cells/tumor tissue are taken advantage for our goal. Currently, mitochondria-targeted photosensitizers are under development. Side effects of chemotherapeutic drugs are not just additional burdens to cancer patients but real problems during the treatments. Selectivity toward cancer cells of drugs is an important issue. Various drug delivery strategies employing nano-technologies (liposomes, polymers, quantum dots, dendrimers, and etc.) have been developed and innovative targeting methods are established for passive and active targeting. Another key factor for successful site-specific drug delivery is how to control the release of drug from such delivery vehicles. Current strategies using enzyme, pH, or chemicals are either physiological condition dependents or not biocompatible. We are developing a new strategy for controlling drug-release with light.

Websites:


Research Projects:

American Cancer Society Research Scholar Grant - Fluorescence cystoscopy-photodynamic Therapy for Early Bladder Cancers. - 7/1/2013 - 6/30/2016
NIR-activatable Prodrugs for Treating Peritoneally Metastasized Ovarian Cancers (NIGMS/NIH R01)
Fluorescence Cystoscopy-photodynamic Therapy for Early Bladder Cancers (American Cancer Society)
A Synergistic Combination Therapy of Photodynamic Therapy and Chemotherapy for Breast Cancer (DoD BCRP idea Expansion Award)
Photo-unclick Chemistry and its Application to Near Infrared-activatable Prodrugs (NIH-NIGMS)

Selected Publications:

Enhanced Singlet Oxygen Generation from a porphyrin-rhodamine B Dyad by two-photon Excitation Through Resonance Energy Transfer
2013    Ngen EJ, Xiao L, Rajaputra P, You Y
Photochem Photobiology
Visible Light Controlled Release of Anti-cancer Drug Through Double Activation of Prodrug.
2013    Hossion AML, Bio M, Nkepang G, Awuah SG, You Y.
ACS Med Chem Lett
Synthesis and in vitro Biological Evaluation of Lipphilic Cation Conjugated Photosensitizers for Targeting Mitochondria
2013    Rajaputra P, Nkepang G, Watley R, You Y.
Bioorg Med Chem
*Synthesis and Singlet Oxygen Reactivity of 1,2-diaryloxyethenes and Selected Sulfur and Nitrogen Analogs.
2012    Nkepang G, Pogula PK, Bio M, You Y.
Photochem. Photobiol.
Core-modified porphyrins. Part 4: Steric effects on photophysical and biological properties in vitro.
   You Y, Scott SL, Hilf R, Ohulchanskyy TY, Detty MR.
Bioorg Med Chem; 13: 2235-2251
Podophyllotoxin derivatives: current synthetic approaches for new anticancer agents.
   You Y.
Curr Pharm Des; 11: 1695-1717
Alkyl and carboxylalkyl esters of 4'-demethyl-4-deoxypodophyllotoxin: synthesis, cytotoxic, and antitumor activity.
   You YJ, Kim Y, Nam NH, Bang SC, Ahn BZ.
Eur J Med Chem; 39: 189-193
Synthesis and cytotoxic activity of A-ring modified betulinc acid derivatives.
   You YJ, Kim Y, Nam NH, Ahn BZ.
Bioorg Med Chem Lett; 13: 3137-3140
Water soluble, core-modified porhyrins. 3. Synthesis, photophysical properties, and in vitro studies of photosensitization, uptake, and localization with carboxylic acid-substituted derivatives.
   You Y, Scott SL, Hilf R, Davies SR, Oseroff AR, Roy I, Ohulchanskyy TY, Bergey EJ, Detty MR.
J Med Chem; 46: 3734-3747
Antitumor activity of unsaturated fatty acid esters of 4'-demethyldeoxypodophyllotoxin.
   You YJ, Kim Y,Nam NH, Ahn BZ.
Bioorg Med Chem Lett; 13: 2629-2632
Dendrimeric organotelluride catalysts for the activation of hyrogen peroxide. Improved catalytic activity through statistical and stereoelectronic effects.
   Ahsan K, Drake MD, Higgs DE, Wojciechowski AL, Tse BN, Beteman MA, You Y, Detty MR.
Organometallics; 22: 2883-2890
Inhibitory effect of Adonis amurensis components on tube-like formation of human umbilical venous cells.
   You YJ, Kim Y, Nam NH, Ahn BZ.
Phytother Res; 17: 568-570
Mechanistic studies of the tellurium(ll)/tellurium(IV) redox cycle in thiol peroxidase-like reactions of diorganotellurides in methanol.
   You Y, Ahsan K, Detty MR.
J Am Chem Soc; 125: 4918-4927
Antiangiogenic activity of lupeol from Bombax ceiba.
   You YJ, Nam NH, Kim Y, Bae KH, Ahn BZ.
Phytother Res; 17: 341-344
Prodrugs of 4'-demethyl-4-deoxypodophyllotoxin: synthesis and evaluation of the antitumor activity.
   Kim Y, You YJ, Nam NH, Ahn BZ.
Bioorg Med Chem Lett; 12: 3435-3438
21-Telluraporphyrins. II. Catalysts for bromination reactions with hydrogen peroxide and sodium bromide.
   Abe M, You Y, Detty MR.
Organometallics; 21: 4546-4551
Antiangiogenic activity of Bupleurum longiradiatum on human umbilical venous endothelial cells.
   You YJ, Lee IS, Kim Y, Bae KH, Ahn BZ.
Arch Pharm Res; 25: 640-642
2,3-Dibenzylbutyrolactones and 1,2,3,4-tetrahydro-2-naphthoic acid gamma-lactones: structure and activity relationship in cytotoxic activity.
   Kim Y, You YJ, Nam NH, Ahn BZ.
Arch Pharm Res; 25: 240-249
*Click and Photo-unclick Chemistry of Aminoacrylate for Visible Light-triggered Drug Release.
   Bio M, Nkepang G, You Y.
Chem. Comm.
Asymmetric ZnPc-Rhodamine B Conjugates for Mitochondrial Targeted Photodynamic Therapy.
   Muli KD, Rajaputra P, You Y, and McGrath DV.
Bioorg. Med. Chem. Lett. 2014, 24, 4496-4500
Core-modified porphyrins. Part 5: Electronic effects on photophysical and biological properties in vitro.
   You Y, Scott SL, Detty MR.
Bioorg Med Chem; 13: 5968-5980
Structure-activity studies of uptake and photoxicity with heavy-chalcogen analogues of tetramethylrosamine in vitro in chemosensitive and multidrug-resistant cells.
   Scott SL, Holt JJ, Ye M, Donnelly DJ, Ohulchanskyy TY, You Y, Detty MR.
Bioorg Med Chem; 13: 6394-6403
Folate Receptor-mediated Enhanced and Specific Delivery of Far-red Light-Activatable Prodrugs of Combretastatin A-4 to FR-positive Tumor.
   Nkepang G., Bio M, Rajaputra P, Awuah S and You Y.
Bioconjugate Chem 2014, 25, 2175-2188
Synthesis, spectral data, and crystal structure of two novel substitution patterns in dithiaporphyrins.
   You Y, Daniels TS, Dominiak PM, Detty MR.
Journal of Porphyrins and Phthalocyanines; 11: 1-8
Phototoxicity of a core-modified porphyrin and induction of apoptosis.
   You Y, Gibson SL, Detty MR.
Journal of Photochemistry and Photobiology B: Biology; 85: 155-162