(Heloise) Anne Pereira

Contact Information:
(Heloise) Anne Pereira


Pereira, Anne (HSC)
Associate Dean of Research and Professor

Department of:

College Of Pharmacy/Pharmaceutical Sciences -Associate Dean of Research and Professor

Center of:

OK Center for Neurosciences -Member


University of Melbourne, Australia   Ph.D., (Pathology)   1982

Professional Interest/Expertise/Specializations:
This laboratory invstigates the role of a novel inflammatory mediator known as CAP37. We focus on the significance of this protein in host defense against severe infections including infections of the eye and in various inflammatory mediated diseases such as atherosclerosis and Alzheimer's disease. We currently employ a combination of cellular, immunological, biochemical and molecular approaches at the in vitro and in vivo level to solve these questions. Our long-term goals are to design new and effective antibiotics and anti-inflammatory therapeutics


Website profile for H.Anne Pereira

Research Projects:

"Antifungal peptides and methods of use thereof." US 60/704,257 (Pending).
OCAST - Role of CAP37 in Neuroinflammation: Friend or Foe. - 7/1/2012 - 6/30/2015
Oklahoma Shared Clinical and Translational Resources (NIH-OSCTR IDeA (U54))
48th Annual Meeting of the Society For Leukocyte Biology-Immunity in Health and Disease (NIH/NIAID)

Selected Publications:

A Multifunctional Peptide Based on the Neutrophil Immune Defense Molecule, CAP37, Has Antibacterial and Wound Healing Properties
2015    Kasus-Jacobi A, Griffith GL, Noor-Mahammadi S, Logan S, Hinsley H, Brevetti J, Mathias L, Pereira HA
J Leukoc Biol
The Antimicrobial Protein, CAP37, is Upregulated in Pyramidal Neurons during Alzheimer's Disease
2015    Brock AJ, Kasus-Jacobi A, Lerner M, Logan S, Adesina AM, Pereira HA
Histochem & Cell Biologoy
Is the Use of Complete Blood Counts with Manual Differentials an Antiquated Method of Determinineg Neutrophil Composition in Newborns?
2015    Lawrence SM, Eckert J, Makoni M, Pereira HA
Annals Clin Lab Sci
A Multifunctional peptide based on the neutrophil immune defense molecule, CAP37, has antibacterial and wound healing properties.
2014    Kasus-Jacobi A, Noor-Mohammadi S, Griffith GL, Hinsley H, Mathias L and Pereira HA
The Journal of Leukocyte Biology
Functional modulation of smooth muscle cells by the inflammatory mediator CAP 37.
   Gonzalez ML, Ruan X, Kumar P, Grammas P, Pereira HA.
Microvasc Res 2004; 67: 168-181
CAP37, a neutrophil-derived inflammatory mediator augments leukocyte adhesion to endothelial monolayers.
   Lee TD, Gonzalez ML, Kumar P, Grammas P, Pereira HA.
Microvasc Res 2003; 66: 38-48
Activation of microglia: a neuroinflammatory role for CAP37.
   Pereira HA, Ruan X, Kumar P.
GLIA 2003; 41: 64-72
Corneal expression of the inflammatory mediator CAP37.
   Ruan X, Chodosh J, Callegan MC, Booth MC, Lee TD, Kumar P, Gilmore MS, Pereira HA.
Invest Ophthalmol Vis Sci 2002; 43: 1414-1421
CAP37, a novel inflammatory mediator: Its expression in endothelial cells and localization to atherosclerotic lesions.
   Lee TD, Gonzalez ML, Kumar P, Chary-Reddy S, Grammas P, Pereira HA.
Amer J Pathol 2002; 160: 841-848.
CAP37, a multifunctional inflammatory protein.
   Pereira HA.
J Chinese Med Assoc 2001; 114: 9-13.
Inducible expression of the inflammatory protein CAP37 in the epidermis during wound healing.
   Pereira HA, Kumar P, Lerner MR, Brackett DJ.
Focus on Protein Res; pp. 127-144. Ed. J.W. Robinson
Modulation of corneal epithelial functions by the neutrophil-derived inflammatory mediator CAP 37.
   Pereira HA, Ruan X, Gonzalez ML, Hoover I, Chodosh J.
Invest Ophthalmol Vis Sci 2004; 45: 4284-4292
Novel therapies based on cationic antimicrobial peptides.
   Pereira HA.
Curr Pharm Biotechnol 2006; 7:229-234
Candidacidal activity of synthetic peptides based on the antibiotic domain of the neutrophil-derived protein, CAP37.
   Pereira HA, Tsyshevskaya-Hoover I, Hinsley H, Logan S, Nguyen M, Nguyen T-T, Pohl J, Wozniak K, Fidel Jr PL.
Medical Mycology 2010; 48: 263-272.
CAP37-derived antimicrobial peptides has in vitro antiviral activity against adenovirus and herpes simplex virus type 1.
   Gordon YJ, Romanowski GG, Shanks RMQ, Yates KT, Hinsley H, Pereira HA.
Curr Eye Res; 2009; 34:241-249