Randy Gallucci

Contact Information:
Randy Gallucci



 

Gallucci, Randy (HSC)
Associate Professor

Department of:

College Of Pharmacy/Pharmaceutical Sciences -Associate Professor of Pharmacology and Toxicology

Center of:

OK Center for Neurosciences -Member

Education:

Washington State University   PhD (Pharmacology/Toxicology)  
BA Central Washington University   Chemistry/Biology  

Professional Interest/Expertise/Specializations:
Specialties Immunopharmacology and immunotoxicology Research Interests The research in my laboratory primarily focuses on the positive roles that endogenous cytokines play during the repair or restoration of injured tissues. I am currently investigating these effects in both skin and liver utilizing both in vivo and in vitro models. The purpose of these studies is two fold: 1) to elucidate the mechanism of, and identify factors involved in, the transcriptional or post-transcriptional regulation of genes modulated by various pro-inflammatory cytokines, and 2) to determine if any of these pro-inflammatory mediators may be useful therapeutically. To investigate the former, we have employed a variety of molecular techniques including, ribonuclease protection assay, genomics arrays, transfection studies, and EMSA. Therapeutic studies have involved the reconstitution of wound healing in immunosuppressed animals (cytokine KO¿s or glucocorticoid treated) using specific recombinant cytokines, or gene therapy utilizing unique expression plasmids.

Websites:

Dr. Galluci website profile

Research Projects:

Potential of noise induced hearing loss by jet fuel (JP-8). (DoD)
8/1/2010-7/31/2013 OCAST/Regular - The role of IL-6 in diabetic wound healing
The role of IL-6 receptor in irritant dermatitis (NIH/CDC/NIOSH)
"Modulation of Inflammatory Mechanisms Underlying Chronic Pain of PTSD and TBI; Prevention and Treatment
Cytokines and Immune Cells in Ovarian Cancer Chemotherapy Resistance

Selected Publications:

IL-6 Deficiency Exacerbates Inflammation in a Murine Model of Irritant Dermatitis
2012    Lee EG, Mickle-Kawar BM, Gallucci RM
Informa Health Care
http://informahealthcare.com/eprint/fDTjYsYmisDFJSUgfGBt/full
IL-6 Deficiency Exacerbates Inflammation in a Mouse Model of Irritant Dermatitis
2012    Lee EG, Mickle-Kawar BM, Ihnat MI, Gallucci RM
J. Immunotox
SOCS3 Modulates IL-6R Signaling Preference in Dermal Fibroblasts.
2012    Luckett-Chastain LR, Mickle-Kawar BM, Ihnat MI, Gallucci RM
J Interferon Cytokine Res
Time-course of mouse bladder inflammation and urinary cytokine release in response to intravesical instillation of BCG, TNF-alpha, and LPS.
2007    Saban MR, Wallis G, Simpson C, Davis C, Knowlton N, Frank MB, Centola M, Gallucci RM, and Saban R,
BMC Immunology 8:6
Stress induced in heart and other tissues by rat dermal exposure to JP-8 fuel.
   Larabee JL, Cheung J, Lerner MR, Lightfoot S, Brackett DJ, Gallucci RM, Hocker JR, and Hanas JS.
Cell Biology and Toxicology. 21: 233-246, 2005
Differential expression of liver IL-6Ra in female vs. male ethanol consuming rats.
   Gallucci RM, Sloan DK, O¿Dell SJ, and Reinke LA.
Alcoholism: Clin. and Exp. Res., March;28(3):1-6, 2004
Interleukin 6 indirectly induces keratinocyte migration.
   Gallucci RM, Sloan DK, O¿Dell SJ, Murray AB, and Heck JM.
J. Inv. Derm 2004; 122:764-772.
Cytokine expression during JP8 jet fuel induced irritant dermatitis in rats.
   Gallucci RM, ODell SJ, Rabe DM, Faulkner DB, and Fechter LD.
J. Immunopharm, Sept;4 (9):1159-1169, 2004
Interleukin 1-dependent regulation of interleukin 6 production by wounding in human epithelial keratinocytes.
   Sugawara T, Gallucci RM, Simeonova PP, and Luster MI.
Cytokine. Sep 21;15(6):328-336, 2001
Interleukin-6 treatment augments cutaneous wound healing in glucocorticoid treated immunosuppressed mice.
   Gallucci RM, Sugawara T, Yucesoy B, BerryAnn K, and Luster MI.
J Interferon Cytokine Res. 2001; 21(8):603-609.
The role of tumor necrosis factor-alpha in liver toxicity, inflammation, and fibrosis induced by carbon tetrachloride.
   Simeonova PP, Gallucci RM, Hulderman T, Wilson R, Kommineni C, Rao M, Luster MI.
Toxicol Appl Pharmacol. Dec 1; 177(2):112-120, 2001
Impaired cutaneous wound healing in IL6-deficient mice.
   Gallucci RM, Simeonova P, Matheson JM, Komenenni C, Guriel J, Luster MI.
Faseb J. 14:2525-2531, 2000
TNF-alpha regulates transforming growth factor-alpha expression in regenerating murine liver and isolated hepatocytes.
   Gallucci RM, Simeonova P, Toriumi W, Luster MI
J Immunol 2000; 164:872-878.
A new enteral mouse model using knockout technology to study early alcohol-induced liver injury: Role of tumor necrosis factor-alpha.
   Yin M, Wheeler MD, Kono H, Bradford BU, Gallucci RM, Luster MI, Thurman RG.
Gastroenterology 1999; 117:942-952.
Cytokine expression in Hepatocytes: Role of oxidant stress.
   Dong W, Gallucci RM, Simeonova P, Matheson JM, Fannin RD, Montuschi P, Flood L, Luster MI.
J Interferon Cytokine Res 1998; 18:629-638.
Ethanol consumption suppresses the IL2-induced proliferation of NK cells.
   Gallucci RM, Meadows GG.
Toxicol Appl Pharmacol1996; 138(1):90-97.
Estrogen Suppresses Hepatic IkB Expression During Short-term Alcohol Exposure
   Lee EG, Mickle-Kawar BM, Reinke LA, Gallucci RM
Inflamm. Res.
Interleukin 6 modulates alpha-smooth muscle actin expression in dermal fibroblasts.
   Gallucci RM, Lee EG, Tomasek JJ.
J Inv Derm 2006;126(3):561-568.
Inflammatory cytokine expression patterns in rat skin exposed to JP-8 jet fuel.
   Gallucci RM, Mickle BM.
Am. J. Pharm. Tox., 1(3):48-53
Interleukin 6 modulates migration and MMP function in dermal fibroblasts from IL6-KO mice.
   Luckett LR, Gallucci RM.
Br. J. Derm 2007; 156(6): 1163-1167.
Interleukin (IL)-6 modulates transforming growth factor-beta expression in skin and dermal fibroblasts from IL-6-deficient mice.
   Luckett-Chastain LR, Gallucci RM.
Br J Dermatol 2009; 161(2): 237-248
Serum profiling of rat dermal explosure to JP-8 fuel reveals an acute-phase response.
   Larabee JL, Hocker JR, Cheung JY, Gallucci RM, Hanas JS.
Toxicology Mechanisms and Methods 2008; 18: 41-51.