Naveena B Janakiram

Contact Information:
Naveena B Janakiram



 

Janakiram, Naveena B. (HSC)
Faculty

Department of:

College Of Medicine/Medicine Hematology/Oncology -Assistant Professor of Research

Center of:

Education:

Osmania University, India   Ph.D in Microbiology  

Professional Interest/Expertise/Specializations:
Colon and pancreatic cancers, NK cells, T regs, Hormone receptors, miRNAs

Websites:

Publications

Research Projects:

Molecular Mechanisms in early stage cancer development: Our research aims to understand the molecular changes that occur during formation and stepwise progression of cancer and to identify specific genes and microRNAs as promising targets for drug development to delay/inhibit/prevent tumor growth.
Major focus of our laboratory aims in the translational research applying rodent models of colon and pancreatic cancers. Some of the important genes identified belong to hormone receptors and their responsive genes with respect to stromal cells in colon tumor development are under experimentation.
Furthermore, currently my focus is also on evaluating the immune mechanisms related to T cells and NK cells in colon and pancreatic carcinogenesis to modulate their effects using combinations of preventive vaccines and effective chemopreventive and therapeutic drugs. The mechanistic basis of these cancer preventive functions is being explored in rodent models of colon and pancreas.
These studies help in understanding and identifying targets and in developing targeted drugs and preventive vaccines for high risk individuals for colon and pancreatic cancers. Works in the lab is funded by an Alumni grant from Dept. Medicine and COBRE pilot project, a NIH Center of Biomedical Research Excellence (CoBRE) grant.

Selected Publications:

Chemopreventive effects of RXR selective rexinoid bexarotene on intestinal neoplasia of ApcMin+/- mice.
2012    Naveena B. Janakiram, Altaf Mohammed, Li Qian, Chang-in-Choi, Vernon E. Steele and Chinthalapally V. Rao
Neoplasia
Prophylactic vaccine approach for colon and pancreatic cancers: Present and Future
2012    Naveena B. Janakiram, Altaf Mohammed, Michael S. Bronze and Chinthalapally V. Rao
Current Medicinal Chemistry
Early Detection and Prevention of Pancreatic Cancer: Use of Genetically Engineered Mouse Models and advanced Imaging Technologies
2012    A. Mohammed, Naveena .B. Janakiram, S. Lightfoot, H. Gali, A. Vibhudutta and C.V. Rao
Current Medicinal Chemistry
Atorvastatin delays progression of pancreatic lesions to carcinoma by regulating PI3/AKT signaling in p48Cre/+ LSL-KrasG12D mice
2012    Altaf Mohammed, Li Qian, Naveena B. Janakiram, Stan Lightfoot, Vernon E. Steele and Chinthalapally V. Rao
International Journal of Cancer
Inhibition of pancreatic intraepithelial neoplasia (PanIN) progression to carcinoma by nitric oxide-releasing aspirin in p48Cre/+-LSL-KrasG12D/+ mice
2012    Rao C.V., Altaf Mohammed, Naveena B. Janakiram, Qian Li, Rebekah L. Ritchie, Stan Lightfoot, Awasthi Vibhudutta and Vernon E. Steele
Neoplasia
Combination of atorvastatin with sulindac or naproxen profoundly inhibits colonic adenocarcinoma by suppressing the p65/beta-catenin/cyclin D1 signaling pathway in rats
2011    Suh N, Reddy BS, Decastro A, Paul S, Lee HJ, Smolarek AK, So JY, Simi B, Wang CX, Naveena B. Janakiram, Steele VE, Rao CV
Cancer Prevention Research
Role of lipoxins, resolvins and other bioactive lipids in colon and pancreatic cancer
2011    Naveena B. Janakiram, Altaf Mohammed, Rao C.V.
Cancer Metastasis Reviews