Vibhudutta Awasthi

Contact Information:
Vibhudutta Awasthi


Awasthi, Vibhudutta (HSC)
Professor and Sandra K. & David L. Gilliland Chair in Nuclear Pharmacy

Department of:

College Of Pharmacy/Pharmaceutical Sciences -Professor

Center of:


Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, Uttar Pradesh (India   PhD (Nuclear Medicine)   1994

Professional Interest/Expertise/Specializations:


Research Projects:

NIH (NCI) R03 - Pancreatic cancer therapy with GRP receptor-targeted imageable diphenyl diphenyl difluoroketone
NIH (NHLBI) R01 - Biologic evaluation of liposome-encapsulated hemoglobin
Awasthi V, Lagisetty P. Anionic lipids and lipid nano-structures and methods of producing the same. US Patent application publication # US2011/0059157 A1; published on March 10, 2011.
A Radiopharmaceutical Kit for PET Renography, Agency: OCAST (HR13-210), 09/01/13-08/31/15

Selected Publications:

Blast Overpressure Waves Induce Transient Anxiety and Regional Changes in Cerebral Glucose Metabolism and Delayed Hyperarousal in Rats
2015    Awwad HO, Goznalez LP, Tompkins P, Lerner M, Brckett DJ, Awasthi V, Standifer KM
Front Neurology
Synthesis and In Vivo Evaluation of Gallium-68 Labeled Glycine and Hippurate Conjugates for PET Renography.
2014    Pathuri G, Madka V, Hedrick AF, Lightfoot SA, Awasthi V, Cowley F BD, Gali H
Mol. Pharm. 2014, 11 2948-2953.
Antibacterial activity of synthetic curcumin derivatives; 3,5-bis (benzylidene)-4 piperidone (EF24) and EF24-dimer linked via diethylenetriaminepentacetic acid (EF2DTPA)
2014    Vilekar P, King C, Lagisetty P, Awasthi V and Awasthi S
Appl Biochem Biotechnol
A "Dose on Demand" Biomarker Generator for Automated Production of {18F}F- and {18F}FDG
2014    Awasthi V, Watson J, Gali H, Matlock G, McFarland A, Bailey J, Anzellotti A
Elsevier - ScienceDirect
Post-blast Treatment with Nociceptin/Orphanin FQ Peptide (NOP) Receptor Antagonist Reduces Brain Ingury-induced Hypoxia and Signaling Protein in Vestibulomotor-related Brain Regions
2014    Awwad HO, Simpson-Durand C, Gonzalez LP, Tompkins P, Zhang Y, Lerner M, Brackett DJ, Sherry DM, Awasthi V, Stanififer KM
Scientifc Reoports
Molecular Basis of 'Hypoxic' Breast Cancer Cell Radio-sensitization: Phytochemicals Converge on Radiation Induced Rel Signaling
2013    Aravindan S, Natarajan M, Herman TS, Awasthi V, Aravindan N.
Radiation Oncology
Modulation of Oxidative Stability of Haemoglobin Inside Liposome-encapsulated Haemoglobin
2013    Awasthi V, Yadav VR, Goins B, Phillips WT.
J Microencapsul
Post-modification of Preformed Liposomes with Novel Non-phospholipid poly(ethylene glycol)-conjugated Hexadeclycarbamoylmethl Hexadecanoic Acid for Enhanced Circulation Persistence in vivo
2013    Nag OK, Yadav VR, Hedrick A, Awasthi V
Intl J Pharmaceut
Pharmacologic suppression of inflammation by a dipheyldifluoroketone, EF24, in a rat model of fixed-volume hemorrhage improves survival.
2013    Yadav V, Sahoo K, Roberts P, Awasthi V
J Pharmacol Exp Therap
2-[3,5-Bis-(2-fluorobenzylidene)-4-piperidon-1-yl]-N-(4-fluorobenzyl)-acetamide and Its Evaluation as an Anticancer Agent
2013    Lagisetty P, Agashe H, Awasthi V ¿
J Chemistry
Evaluation of 99mTc-probestin for imaging APN expressing tumors by SPECT.
2013    Pathuri G, Hedrick AF, Awasthi V, Ihnat MA, Gali H
Bioorg. Med. Chem. Lett.
Pre-clinical evaluation of CLEFMA, 4-(3,5-bis(2-chlorobenzylidene)-4-oxo-piperidine-1-yl)-4-oxo-2-butenoic acid in a mouse model of lung cancer xenograft.
2013    Yadav V, Sahoo K, Awasthi V
British J Pharmacol
Synthesis and Evaluation of Novel Tc-99m Labeled Probestin Conjugates for Imaging APN/CD13 Expression in vivo.
2012    Ihnat MA, Awasthi V, Gali H.
Bioconjugate Chem
Early Detection and Prevention of Pancreatic Cancer: Use of Genetically Engineered Mouse Models and Advanced Imaging Technologies
2012    Mohammed A, Janakiram NB, Lightfoot S, Gali H, Awasthi V and Rao CV
Curr. Med. Chem
Synthesis and Biodistribution Studies of Technetium-99m-labeled Aminopeptidase N Inhibitor Conjugates
2012    Pathuri G, Hedrick AF, Disch BC, Ihnat MA, Awasthi V, Gali H.
Bioorganic & Medicinal Chemistry Letters
Improved formulation of liposome-encapsulated hemoglobin with an anionic non-phospholipid.
   Agashe H, Lagisetty P, Awasthi S, Awasthi V.
Colloids Surf B 2010; 75: 573-583
Radiosynthesis and in vivo evaluation of a F-18-labeled pancreatic islet amyloid inhibitor.
   Pathuri G, Agashe HB, Awasthi V, Gali H.
J Label Compd Radiopharm 2010; 53(4): 186-191
Neutral and anionic liposome-encapsulated hemoglobin: Effect of postinserted poly(ethylene glycol)-disteroylphosphatidylethanolamine on distribution and circulation kinetics.
   Awasthi VD, Garcia D, Klipper R, Goins BA, Phillips WT.
J Pharmacol Exp Ther 2004; 309(1):241-8.
Kinetics of liposome-encapsulated hemoglobin after 25% hypovolemic exchange transfusion.
   Awasthi VD, Garcia D, Klipper R, Phillips WT, Goins BA.
Int J Pharm 2004; 283(1-2): 53-62.
Biodistribution of radioiodinated adenovirus fiber protein knob domain after intravenous injection in mice.
   Awasthi VD, Meinken G, Springer K, Srivastava SC, Frimuth P.
J Virol 2004; 78(12):6431-8.
Pharmaceutical aspects of hemoglobin-based oxygen carriers.
   Awasthi VD.
Review article. Curr Drug Del 2005; 2:133-142.
[99-m Tc] Liposomes for localizing experimental colitis in a rabbit model.
   Awasthi VD, Goins B, McManus L, Klipper R, Phillips WT.
Nucl Med Biol 2003; 30:159-168
Insertion of poly(ethylene glycol) lipid reduces the liposome-encapsulated hemoglobin-induced thrombocytopenic reaction.
   Awasthi V, Goins B, Phillips WT.
Am J Pharmacol Toxicol 2007; 2(2): 98-105
Cerebral oxygen delivery by liposome-encapsulated hemoglobin: A positron-emission tomographic evaluation in a rat model of hemorrhagic shock.
   Awasthi V, Yee SH, Jerabek P, Goins B, Phillips WT.
J Appl Physiol 2007; 103(1): 28-38
Magnetically-targeted technetium 99m-labeled nanoparticles to the inner ear.
   Dormer KJ, Awasthi V, Galbraith W, Kopke D, chen K, Wassel R.
J Biomed Nanotechnology 2008; 4(2): 174-184
Synthesis of radiolabeled cytarabine conjugates.
   Lagisetty P, Vilekar P, Awasthi V.
Bioorg Med Chem Lett 2009; 19: 4764-4767
Circulation and biodistribution profiles of long-circulating PEG--liposomes of various sizes in rabbits.
   Awasthi VD, Garcia D, Goins BA, Phillips WT.
Int J Pharmaceutics 2003; 253:121-132.
Accumulation of PEG-liposomes in the inflamed colon of rats: Potential for therapeutic and diagnostic targeting of inflammatory bowel diseases. J
   Awasthi VD, Goins B, Klipper R, Phillips WT.
Drug Targeting 2002; 10:419-427.
Efficacy of Ag2/PRA cDNA-transfected dendritic cells in immunization of mice against Coccidioides posadasil.
   Awasthi S, Awasthi VD, Magee DM, Coalson JJ.
J Immunol 2005; 175(6):3900-06.
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