Madeleine W. Cunningham

Contact Information:
Madeleine W. Cunningham


Cunningham, Madeleine W. (HSC)
George Lynn Cross Proessor

Department of:

College Of Medicine/Microbiology & Immunology -Professor

Center of:


University of Tennessee Center for the Health Sciences   Ph.D.   1973
University of Tennessee Center for the Health Sciences   M.S.   1971
Mississippi State College for Women   B.S.   1968

Professional Interest/Expertise/Specializations:
Dr. Madeleine Cunningham has focused for 30 years on molecular mimicry, autoimmunity and infection in studies of inflammatory heart diseases related to streptococci and viruses. Her work involves studies of the pathogenensis of rheumatic carditis, myocarditis and cardiomyopathy as well as the fetal heart disease hypoplastic left ventricle syndrome(HLHS). A second area of her research focuses on the brain and the pathogenesis of movement and behavioral disorders associated with streptococci, including Sydenham chorea, the neurologic manifestation of rheumatic fever, and pediatric autoimmune neurologic disorder associated with streptococci (PANDAS). Currently her laboratory is involved in studies of human diseases, to improve their diagnosis and treatment and determine how infections play a role in autoimmune diseases of the heart and brain. Her laboratory studies both B and T cell immunology as well as neuronal and cardiomyocyte cell signaling. Dr. Cunningham is the director of the NIAID supported Immunology Training Program at the University of Oklahoma for the past 10 years. She has been the recipient of NHLBI Career Development and MERIT Awards and has been funded NIH for the past 25 years.


Microbiology Website, Dr. Cunningham

Research Projects:

Selected Publications:

Activating autoantibodies to the beta-1 adrenergic and m2 muscarinic receptors facilitate atrial fibrillation in patients with Graves' hyperthyroidism
2009    Stavrakis, S., Yu, X., Patterson, E., Huang, S., Hamlett, S. R., Chalmers, L., Pappy, R., Cunningham, M. W., Morshed, S. A.. Davies, T. F., Lazzara, R., Kem, D. C.
J Am Coll Cardiol
Cutting Edge: Cardiac myosin activates innate immune responses through Toll-like receptors (TLRs).
2009    Zhang, P., Cox, C. J., K. M. Alvarez, and M.W. Cunningham.
Journal of Immunology
Development of cardiomyopathy and atrial tachyarrhythmias associated with activating autoantibodies to beta-adrenergic and muscarinic receptors
2009    Yu, X. E. Patterson, S. Stavrakis, S. Huang,, I. De Aos, S. Hamlett, M.W. Cunningham, R. Lazarra, D. C. Kem.
J. Am. Soc. Hypertension
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