Garo P. Basmadjian

Contact Information:
Garo P. Basmadjian


Basmadjian, Garo P. (HSC)
Professor (Emeritus)

Department of:

College Of Pharmacy/Pharmaceutical Sciences -Professor (Emeritus)

Center of:


Purdue University, Indiana   Ph.D. (Medicinal Chemistry - Natural Products Chemistry)   1970

Professional Interest/Expertise/Specializations:
Design, synthesis and animal evaluation of novel radiopharmaceuticals labeled with positron emitting radioisotopes like C-11 and F-18. The main purpose for these radiopharmaceuticals will be their use for human Positron Emission Tomography (PET) studies in oncology, cardiology and neurology. To identify therapeutic agents for nervous system disorders including cognitive and attention disorders, Alzheimer¿s disease, Parkinson disease and nicotine addiction among the class of selective nicotinic acetylcholine receptor agonists. Phytomedicinals, Nutraceuticals, Herbal Medicine, Natural Products Chemistry. The design of extraction protocols of natural herbs and drugs and the HPLC analysis of herbal drugs and mixtures to identify active constituents.


Research Projects:

Selected Publications:

Design and synthesis of isoxazole containing bioisosteres of epibatidine as potent nicotinic acetylcholine receptor agonists.
1999    Singh S, Avor KS, Pouw B, Seale TW, Basmadjian GP.
Chem Pharm Bull (Tokyo) 47(10):1501-5
Synthesis and dopamine transporter binding of 2'-isopropyl ester analogs of cocaine.
   El-moselhy TF, Avor KS, Basmadjian GP.
Eur. J. Med. Chem. 37, 171-176
2-Substituted analogs of cocaine: synthesis and dopamine transporter binding potencies.
   El-Moselhy TF, Avor KS, Basmadjian GP.
Arch. Pharm. Pharm. Med. Chem. 334, 275-278
2b-Substituted analogues of 4¿-Iodococaine: Synthesis and Dopamine Transporter Binding Potencies.
   Avor KS, Singh S, Seale TW, Pouw B and Basmadjian GP.
J. Med. Chem. 41, 2380-2389, 1998
Design of Novel Nicotinic Acetylcholine Receptor Agonists with Potential Antinociceptive Activity.
   Basmadjian GP, Singh S, Avor K, Pouw B and Seale TW.
In Pain Mechanisms and Management, S.N. Ayrapetian and A.V. Apkarian eds. IOS Press, 1998. Pp. 285-300
Inherited, selective hypoanalgesic response to cytisine in the tail-flick test in CF-1 mice.
   Seale TW, Nael R, Singh S and Basmadjian GP.
NeuroReport 9, 201-205, 1998
Extracts of kava (Piper methysticum) induce acute anxiolytic-like behavioral changes in mice.
   Garrett, KM, Basmadjian G, Khan IA, Seale TW.
Psychopharmacology 170, 33-41
Synthesis and dopamine transporter binding of 2¿-substituted cocaine analogs.
   El-moselhy TF, Avor KS, Basmadjian GP.
Med. Chem. Research 10/1, 50-57
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