David W.A. Bourne

Contact Information:
David W.A. Bourne


Bourne, David (HSC)
Professor (Retired)

Department of:

College Of Pharmacy/Pharmaceutical Sciences -Professor

Center of:

Other Organization:

University of Colorado, School of Pharmacy -Adjoint Professor


Ph.D., University of Kansas - Victorian College of Pharmacy   PhD   1974

Professional Interest/Expertise/Specializations:
Research interests include the study of pharmacokinetic models; especially physiologically based models, models involving protein binding, pharmacodynamic models and the development of computer programs for pharmacokinetic analysis. Recent work has included the development of models for cephalosporin and sulfonamide disposition including protein binding; oral and Intranasal administration of selected drugs and comparison with IV administration; and the influence of zero gravity of drug absorption and disposition. Computer programs include BOOMER a general purpose non-linear regression and simulation program written in FORTRAN for the Macintosh and PC desktop computers. Ancillary to the study of pharmacokinetic models is the development of drug analysis techniques, especially high pressure liquid chromatography. Use of the Internet as a research and teaching resource is a major interest. Recent interest in nanoparticle development.


Research Projects:

Selected Publications:

Effects of Cytochrome P450 2C8*3 on the Population Pharmacokinetics in Healthy Caucasian Volunteers
2013    Kadam R, Bourne DWA, Kompella U, Aquilante C.
Bio Pharm Bull
Magnetic Targeted Delivery of Dexamethasone Acetate Across the Round Window Membrane in Guinea Pigs
2013    Du X, Kuriyavar S, Kopke RD, Grady BP, Bourne DWA, Li W, Dormer KJ.
Audio Neurotol
Impact of the CYP2C8*3 Polymorphism on the Drug-drug interaction Between Gemfibrozil and Pioglitazone
2013    Aquilante C, Kosmiski L, Bourne DWA, Bushman L, Daily E, Hammond K, Hopley C, Kadam R, Kanack A, Kompella U, Le M, Predhomme J, Rower J, Sidhom M.
Brit J Clin Pharmacol
Regression of Glioma Tumor Growth in F98 and U87 Rat Glioma Models by the Nitrone, OKN-007.
2013    Towner RA, Gillespie DL, Schwager A, Saunders D, Smith N, Njoku C, Krysiak R, Larabee C, Iqbal H, Floyd RA, Bourne DWA, Abdullah O, Hsu EW, Jensen RL.
Basic Pharmacokinetics (the short version)
2012    Bourne, DWA
Nano-advantage in enhanced Drug Delivery with Biodegradable Nanoparticles: Contribution of Reduced Clearance
2012    Kadam RS, Bourne DWA, Kompella UB.
Drug Metabolism and Disposition
2012 Basic Pharmacokinetics
2012    Bourne, DWA
Impact of the CYP2C8*3 Polymorphism on the Drug-Drug Interaction Between Gemfibrozil and Pioglitazone
2011    Auilante C, Kosmiski L, Bourne DWA, Bushman L, Daily E, Hammond K, Hopley C, Kadam R, Kanack A, Kompella U, Le M, Predhomme J, Rower J, and Sidhom M.
British Journal of Clinical Pharmacology
A Trek Through CyberSpace,
   Bourne, D.W.A., Hogkinson, P., McLean, S.
Amer. J. Pharm. Ed., 59, 402-408
Bioavailability of Intranasal Scopolamine in Normal Subjects,
   Putcha, L., Tietze, K.J., Bourne, D.W.A., Parise, C.M., Hunter, R.P., Cintron, N.M.
J. Pharm. Sci., 85(8), 899-902
Mathematical Modeling of Pharmacokinetic Data,
   Bourne, D.W.A.
Technomic Publishing Co., Lancaster, PA
Incorporation, release and effectiveness of dexamethasone in poly(lactic-co-glycolic acid) nanoparticles for inner ear drug delivery
   Bourne, DWA
J Nanotech Engineer Med 2, 011013.
Influence of the CYP2C8*3 Polymorphism on the Population Pharmacokinetics of Pioglitazone in Healthy Volunteers
   Kadam RS, Kompella UP, Bourne DWA, and Aquilante C.
Poster : Pharmaceutical Sciences Research Symposium, University of Colorado, Aurora
New high-performance liquid chromatographic method for amphotericin B analysis using an internal standard,
   Polikandritou Lambros, M., Abbas, S.A., and Bourne, D.W.A.
J. Chromatog. B: Biomed. Applic., 685, 135-140
Disposition of Aerosolized Liposomal Amphotericin B,
   Polikandritou Lambros, M., Bourne, D.W.A., Abbas, S.A., Johnson, D.L.
J. Pharm. Sci., 86, 1066-1069
Using the Internet as a Pharmacokinetic Resource,
   Bourne, D.W.A.
Clinical Pharmacokinetics, 33, 153-160
Gastrointestinal Absorption of Phenytoin from an Oil-in-water Microemulsion,
   Kwon, K.I. and Bourne, D.W.A.
Arch. Pharm. Res., 20(5), 480-485
2012 Basic Pharmacokinetics
   Bourne DWA
Apple iTunes Bookstore
2012 Pharmacy Math Part 1
   Bourne, DWA
Apple iTunes Bookstore
2012 Pharmacy Math Part 2
   Bourne, DWA
Apple iTunes Bookstore
2012 Basic Pharmacokinetics: Truncated,
   Bourne, DWA
Apple iTunes Bookstore
2012 Boomer Manual: Basic
   Bourne, DWA
Apple iTunes Bookstore
2012 Pharmacy Math: A Preview
   Bourne, DWA
Apple iTunes Bookstore
Bioavailability of intranasal promethazine doage forms in dogs,
   Ramanathan, R., Geary, R.S., Bourne, D.W.A., and Putcha, L.
Pharmacological Research, 38(1), 35-39
A Liquid Chromatographic Method for the Simultaneous Determination of Promethazine and Three of Its Metabolites in Plasma Using Electrochemical and UV Detectors,
   Vanapalli, S.R., Kambhampati, S.P., Putcha, L., and Bourne, D.W.A.
J. Chromatographic Sciences, 39(2), 70-72
Pharmacokinetics of valacyclovir in the adult hore.
   Maxwell LK, Bentz BG, Bourne DWA, Erkert RS.
J Vet Pharmacol Therap; 31:312-320
Pharmacokinetics. In Modern Pharmaceutics.
   Bourne, D.W.A. and Dittert, L.W.
Banker, G.S. and Rhodes, C.T. eds, 3rd ed., Marcel Dekker, New York, NY
Keywords, Tags: