Carr, Dan J. (HSC)
University of Texas Medical Branch
Dan Carr, Ph.D. investigates the host immune response to the highly prevalent human virus pathogens, herpes simplex virus (HSV) types 1 & 2. In mouse ocular (HSV-1) and genital (HSV-2) models of infection, the role of chemokines and their receptors in the generation and recruitment of effector cells (T and NK cells) in response to infection is currently under evaluation.
A functional type I interferon pathway drives resistance to cornea herpes simplex virus type 1 infection by recruitment of T lymphocytes.
Conrady, C.D., H. Jones, M. Zheng, and D.J.J. Carr
J. of Biomedical Res
The loss of the type I interferon pathway increases vulnerability of mice to genital HSV-2 infection.
Conrady, C.D., W.P. Halford, and D.J.J. Carr
VEGF-A expression by HSV-1-infected cells drives corneal lymphangiogenesis.
Wuest, T.R. and D.J.J. Carr
J. Exp. Med