Parthasarathy Chandrakesan

Contact Information:
Parthasarathy Chandrakesan



 

Chandrakesan, Parthasarathy (HSC)
Faculty

Department of:

College Of Medicine/Medicine - Gastroenterology -Assistant Professor of Research

Center of:

Peggy & Charles Stephenson Oklahoma Cancer Center -Associate Member

Education:

University of Madras   MS. in Molecular Biology   1999
University of Madras   M.Phil. in Endocrinology   2000
University of Madras   Ph.D. in Molecular and Reproductive Endocrinology   2008

Professional Interest/Expertise/Specializations:
A) Molecular characterization of stem cells under normal condition and after injury. B) Functional importance of Dclk1 to maintain stem cells, pluripotency and survival. C) Cell of origin of cancer. D) Molecular associations between Cancer stem cells and epithelial mesenchymal transition (EMT) for cancer progression, survival and recurrence. E) Targeted therapies using novel nanotechnology and combination machinery for Pancreatic, Breast and Colon cancers. F) Signaling machinery and miRNA deviations as new targets to enhance the sensitivity of cancer cells and cancer stem cells for chemotherapy

Websites:

Department of Internal Medicine-Faculty Listing
Department of Internal Medicine-Section of Digestive Diseases and Nutrition

Research Projects:

Selected Publications:

Dclk1+ small intestinal epithelial tuft cells display the hallmarks of quiescence and self-renewal.
2015    Chandrakesan P, May R, Qu D, Weygant N, Taylor VE, Li JD, Ali N, Sureban SM, Qante M, Wang TC, Bronze MS, Houchen CW.
Oncotarget. 2015 Oct 13;6(31):30876-86. doi: 10.18632/oncotarget.5129 PMID: 26362399
http://www.impactjournals.com/oncotarget/index.php?journal=oncotarget&page=article&op=view&path[]=5129&pubmed-linkout=1
Steric Crowding of the Turn Region Alters the Tertiary Fold of Amyloid-ß18-35 and Makes It Soluble.
2015    Chandrakesan M, Bhowmik D, Sarkar B, Abhyankar R, Singh H, Kallianpur M, Dandekar SP, Madhu PK, Maiti S, Mithu VS
J Biol Chem. 2015 Dec 11;290(50):30099-107. doi: 10.1074/jbc.M115.674135. Epub 2015 Oct 20 PMID: 26487720
Ablation of Doublecortin-Like Kinase 1 in the Colonic Epithelium Exacerbates Dextran Sulfate Sodium-Induced Colitis
2015    Qu D, Weygant N, May R, Chandrakesan P, Madhoun M, Ali N, Sureban SM, An G, Schlosser MJ, Houchen CW
PLoS One. 2015 Aug 18;10(8):e0134212. doi: 10.1371/journal.pone.0134212. eCollection 2015 PMID: 26285154
http://www.plosone.org/article/fetchObject.action?uri=info:doi/10.1371/journal.pone.0134212&representation=PDF
Dietary Pectin Increases Intestinal Crypt Stem Cell Survival following Radiation Injury.
2015    Sureban SM, May R, Qu D, Chandrakesan P, Weygant N, Ali N, Lightfoot SA, Ding K, Umar S, Schlosser MJ, Houchen CW
PLoS One. 2015 Aug 13;10(8):e0135561. doi: 10.1371/journal.pone.0135561. eCollection 2015 PMID: 26270561
http://www.plosone.org/article/fetchObject.action?uri=info:doi/10.1371/journal.pone.0135561&representation=PDF
Inflammatory and oncogenic roles of a tumor stem cell marker doublecortin-like kinase (DCLK1) in virus-induced chronic liver diseases.
2015    Ali N, Chandrakesan P, Nguyen CB, Husain S, Gillaspy AF, Huycke M, Berry WL, May R, Qu D, Weygant N, Sureban SM, Bronze MS, Dhanasekaran DN, Houchen CW
Oncotarget. 2015 Aug 21;6(24):20327-44 PMID: 25948779
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4653008/pdf/oncotarget-06-20327.pdf
Doublecortin-like kinase 1 is elevated serologically in pancreatic ductal adenocarcinoma and widely expressed on circulating tumor cells
2015    Qu D, Johnson J, Chandrakesan P, Weygant N, May R, Aiello N, Rhim A, Zhao L, Zheng W, Lightfoot S, Pant S, Irvan J, Postier R, Hocker J, Hanas JS, Ali N, Sureban SM, An G, Schlosser MJ, Stanger B, Houchen CW
PLoS One. 2015 Feb 27;10(2):e0118933. eCollection 2015. PMID: 25723399
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4344195/pdf/pone.0118933.pdf
DCLK1 is a broadly dysregulated target against epithelial-mesenchymal transition, focal adhesion, and stemness in clear cell renal carcinoma
2015    Weygant N, Qu D, May R, Tierney RM, Berry WL, Zhao L, Agarwal S, Chandrakesan P, Chinthalapally HR, Murphy NT, Li JD, Sureban SM, Schlosser MJ, Tomasek JJ, Houchen CW
Oncotarget. 2015 Feb 10;6(4):2193-205. PMID: 25605241
http://www.impactjournals.com/oncotarget/index.php?journal=oncotarget&page=article&op=view&path[]=3059
Plasma DCLK1 is a marker of hepatocellular carcinoma (HCC): Targeting DCLK1 prevents HCC tumor xenograft growth via a microRNA-dependent mechanism.
2015    Sureban SM, Madhoun MF, May R, Qu D, Ali N, Fazili J, Weygant N, Chandrakesan P, Ding K, Lightfoot SA, Houchen CW
Oncotarget. 2015 Nov 10;6(35):37200-15. doi: 10.18632/oncotarget.5808. PMID: 26468984
http://www.impactjournals.com/oncotarget/index.php?journal=oncotarget&page=article&op=view&path[]=5808&pubmed-linkout=1
DCLK1 facilitates intestinal tumor growth via enhancing pluripotency and epithelial mesenchymal transition
2014    Chandrakesan P, Weygant N, May R, Qu D, Chinthalapally HR, Sureban SM, Ali N, Lightfoot SA, Umar S, Houchen CW
Oncotarget. 2014 Oct 15;5(19):9269-80. PMID: 25211188
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4253433/pdf/oncotarget-05-9269.pdf
XMD8-92 inhibits pancreatic tumor xenograft growth via a DCLK1-dependent mechanism
2014    Sureban SM, May R, Weygant N, Qu D, Chandrakesan P, Bannerman-Menson E, Ali N, Pantazis P, Westphalen CB, Wang TC, Houchen CW
Cancer Lett. 2014 Aug 28;351(1):151-61. Epub 2014 May 28. PMID: 24880079
http://www.sciencedirect.com/science/article/pii/S0304383514002687
Small molecule kinase inhibitor LRRK2-IN-1 demonstrates potent activity against colorectal and pancreatic cancer through inhibition of doublecortin-like kinase 1
2014    Weygant N, Qu D, Berry WL, May R, Chandrakesan P, Owen DB, Sureban SM, Ali N, Janknecht R, Houchen CW
Mol Cancer. 2014 May 6;13:103. PMID: 24885928
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4030036/pdf/1476-4598-13-103.pdf
Fluvastatin interferes with hepatitis C virus replication via microtubule bundling and a doublecortin-like kinase-mediated mechanism
2013    Ali N, Allam H, Bader T, May R, Basalingappa KM, Berry WL, Chandrakesan P, Qu D, Weygant N, Bronze MS, Umar S, Janknecht R, Sureban SM, Huycke M, Houchen CW
PLoS One. 2013 Nov 19;8(11):e80304. PMID: 24260365
http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0080304
Inhibition of Notch signaling reduces the number of surviving Dclk1+ reserve crypt epithelial stem cells following radiation injury
2013    Qu D, May RJ, Sureban SM, Weygant N, Chandrakesan P, Ali N, Li L, Barrett TA, Houchen CW
Am J Physiol Gastrointest Liver Physiol. 2014 Mar 1;306(5):G404-11. PMID: 24368703
http://ajpgi.physiology.org/content/ajpgi/early/2013/12/20/ajpgi.00088.2013.full.pdf
DCLK1 regulates pluripotency and angiogenic factors via microRNA-dependent mechanisms in pancreatic cancer
2013    Sureban SM, May R, Qu D, Weygant N, Chandrakesan P, Ali N, Lightfoot SA, Pantazis P, Rao CV, Postier RG, Houchen CW
PLoS One. 2013 Sep 9;8(9):e73940. PMID: 24040120
http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0073940
Differential Effects of ß-catenin and NF-kB Interplay in the Regulation of Cell Proliferation, Inflammation and Tumorigenesis in Response to Bacterial Infection
2013    Chandrakesan P, Jakkula LU, Ahmed I, Roy B, Anant S, Umar S
PLoS One. 2013 Nov 21;8(11):e79432. PMID: 24278135
http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0079432
Dclk1 deletion in tuft cells results in impaired epithelial repair after radiation injury
2013    May R, Qu D, Weygant N, Chandrakesan P, Ali N, Lightfoot SA, Li L, Sureban SM, Houchen CW
Stem Cells. 2014 Mar;32(3):822-7. PMID: 24123696 Brief Report
http://onlinelibrary.wiley.com/doi/10.1002/stem.1566/abstract
Utility of a bacterial infection model to study epithelial-mesenchymal transition, mesenchymal-epithelial transition or tumorigenesis
2013    Chandrakesan P, Roy B, Jakkula LU, Ahmed I, Ramamoorthy P, Tawfik O, Papineni R, Houchen C, Anant S, Umar S
Oncogene. 2014 May 15;33(20):2639-54. PMID: 23752178
http://www.nature.com/onc/journal/vaop/ncurrent/full/onc2013210a.html
Evidence of functional cross talk between the Notch and NF-kB pathways in nonneoplastic hyperproliferating colonic epithelium
2013    Ahmed I, Roy B, Chandrakesan P, Venugopal A, Xia L, Jensen R, Anant S, Umar S
Am J Physiol Gastrointest Liver Physiol. 2013 Feb 15;304(4):G356-70. PMID: 23203159
http://ajpgi.physiology.org/content/304/4/G356