Naushad Ali

Contact Information:
Naushad Ali



 

Ali, Naushad (HSC)
Faculty

Department of:

College Of Medicine/Medicine - Gastroenterology -Assistant Professor of Research

Center of:

Peggy & Charles Stephenson Oklahoma Cancer Center -Member

Education:

Aligarh Muslim University (AMU), Aligarh   B. Sc. Chemistry Hons.   1984
Aligarh Muslim University (AMU), Aligarh   M. Sc   1986
Aligarh Muslim University (AMU), Aligarh   M. Phil.   1988
Aligarh Muslim University (AMU), Aligarh   Ph.D.   1992
University of Colorado Health Sciences Center (UCHSC)   Postdoctoral Fellow   1994

Professional Interest/Expertise/Specializations:
Dr. Ali's current research interests are: * Hepatitis C virus (HCV)-induced hepatocellular carcinoma (HCC), tumor/cancer stem cells (CSCs), treatment of liver diseases, hepatocyte plasticity and liver tissue regeneration*. Dr. Ali is conducting research on the signaling network of a tumor stem marker, Doublecortine kinase (DCLK1) in liver diseases, mechanism of virus-induced hepatic inflammation and cirrhosis, and cancer treatment by targeting tumor stem-like cells. His research interests also include molecular mechanism of protein synthesis in normal and disease conditions.

Websites:

Department of Internal Medicine-Section of Digestive Diseases and Nutrition
Peggy and Charles Stephenson Cancer Center
Department of Internal Medicine-Faculty Listing

Research Projects:

Cobre: Novel Strategies for Targeting Cancer Stem-like Cells Expressing Hepatitis C Virus (PI for Pilot Project) 09/01/12-08/31/17

Selected Publications:

DCLK1 facilitates intestinal tumor growth via enhancing pluripotency and epithelial mesenchymal transition
2015    Chandrakesan P, Weygant N, May R, Qu D, Chinthalapally HR, Sureban SM, Ali N, Lightfoot SA, Umar S, Houchen CW
Oncotarget. 2014 Oct 15;5(19):9269-80. PMID: 25211188
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4253433/pdf/oncotarget-05-9269.pdf
Doublecortin-like kinase 1 is elevated serologically in pancreatic ductal adenocarcinoma and widely expressed on circulating tumor cells
2015    Qu D, Johnson J, Chandrakesan P, Weygant N, May R, Aiello N, Rhim A, Zhao L, Zheng W, Lightfoot S, Pant S, Irvan J, Postier R, Hocker J, Hanas JS, Ali N, Sureban SM, An G, Schlosser MJ, Stanger B, Houchen CW
PLoS One. 2015 Feb 27;10(2):e0118933. eCollection 2015. PMID: 25723399
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4344195/pdf/pone.0118933.pdf
XMD8-92 inhibits pancreatic tumor xenograft growth via a DCLK1-dependent mechanism
2014    Sureban SM, May R, Weygant N, Qu D, Chandrakesan P, Bannerman-Menson E, Ali N, Pantazis P, Westphalen CB, Wang TC, Houchen CW
Cancer Lett. 2014 Aug 28;351(1):151-61. Epub 2014 May 28. PMID: 24880079
http://www.sciencedirect.com/science/article/pii/S0304383514002687
Small molecule kinase inhibitor LRRK2-IN-1 demonstrates potent activity against colorectal and pancreatic cancer through inhibition of doublecortin-like kinase 1
2014    Weygant N, Qu D, Berry WL, May R, Chandrakesan P, Owen DB, Sureban SM, Ali N, Janknecht R, Houchen CW
Mol Cancer. 2014 May 6;13:103. PMID: 24885928
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4030036/pdf/1476-4598-13-103.pdf
Conducting scaffolds for liver tissue engineering
2014    Rad AT, Ali N, Kotturi HS, Yazdimamaghani M, Smay J, Vashaee D, Tayebi L
J Biomed Mater Res A. 2014 Nov;102(11):4169-81. Epub 2014 Feb 5. PMID: 24443356
http://www.ncbi.nlm.nih.gov/pubmed/?term=10.1002%2Fjbm.a.35080
Brief report: Dclk1 deletion in tuft cells results in impaired epithelial repair after radiation injury
2014    May R, Qu D, Weygant N, Chandrakesan P, Ali N, Lightfoot SA, Li L, Sureban SM, Houchen CW
Stem Cells. 2014 Mar;32(3):822-7. PMID: 24123696
http://www.ncbi.nlm.nih.gov/pubmed/24123696
Fluvastatin interferes with hepatitis C virus replication via microtubule bundling and a doublecortin-like kinase-mediated mechanism
2013    Ali N, Allam H, Bader T, May R, Basalingappa KM, Berry WL, Chandrakesan P, Qu D, Weygant N, Bronze MS, Umar S, Janknecht R, Sureban SM, Huycke M, Houchen CW
PLoS One. 2013 Nov 19;8(11):e80304. PMID: 24260365
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3833963/pdf/pone.0080304.pdf
Hepatitis C virus-induced cancer stem cell-like signatures in cell culture and murine tumor xenografts
2011    Ali N1, Allam H, May R, Sureban SM, Bronze MS, Bader T, Umar S, Anant S, Houchen CW
J Virol. 2011 Dec;85(23):12292-303. Epub 2011 Sep 21. PMID: 21937640
http://www.ncbi.nlm.nih.gov/pubmed/21937640
Initiation factor eIF2-independent mode of c-Src mRNA translation occurs via an internal ribosome entry site
2010    Allam H1, Ali N
J Biol Chem. 2010 Feb 19;285(8):5713-25. Epub 2009 Dec 22. PMID: 20028973
http://www.ncbi.nlm.nih.gov/pubmed/20028973