William M. Tierney

Contact Information:
William M. Tierney


Tierney, William M. (HSC)

Department of:

College Of Medicine/Medicine - Gastroenterology -David Ross Boyd Professor of Medicine

Center of:


Yale University School of Medicine   MD   1990
Internal Medicine, Hospital of the University of Pennsylvania   Internship   1991
Internal Medicine, Hospital of the University of Pennsylvania   Residency   1993
Gastroenterology, University of Michigan Medical Center   Fellowship   1997

Professional Interest/Expertise/Specializations:
Dr. Tierney's clinical/research interests are: Colon Cancer Screening, Endoscopic Ultrasound, Pancreatic Diseases and Biliary Diseases. His clinical focus is pancreatic, esophageal and colon cancer. His research interests have included examining the impact of pancreatic cancer staging strategies on patient outcomes and the processes of care in colorectal cancer screening. Dr. Tierney currently serves as Site Investigator for a VA Cooperative Study, Colonoscopy vs. Fecal Immunochemical Test in Reducing Mortality from Colorectal Cancer, a comparative effectiveness study of the screening colonoscopy for colorectal cancer or the annual stool testing with a Fecal Immunochemical Test. He is also currently involved in research projects on the role of stem cells in patients suspected of pancreatic and esophageal cancer. Dr. Tierney has grant funding through a number of organizations and has an excellent publication record. He has published research in the journal; Cell, Journal of Biological Chemistry, American Journal of Gastroenterology, and in Gastrointestinal Endoscopy. Collectively Dr. Tierney has published greater than 100 manuscripts and abstracts, many of which have resulted in video, poster and oral presentations at national meetings. Many of his publications have been completed with junior faculty and fellows reflecting his commitment to serving as a research mentor, opening their minds to clinical research and propelling their academic careers. Nationally, he has served as a councilor on the governing board of the American Society of Gastrointestinal Endoscopy (ASGE) and has been a member and/or chaired a number of ASGE committees which has resulted in a large number of publications defining practice guidelines and use of endoscopic technology for patient care.


Department of Internal Medicine-Section of Digestive Diseases and Nutrition
Department of Internal Medicine-Faculty Listing
Veterans Affairs Medical Center-Physician Listing

Research Projects:

1. VA Office of Research, Cooperative Studies Program: #577 Randomized Trial of Colonoscopy versus Fecal Immunochemical Testing for Colorectal Cancer Screening, Local Site PI- Oklahoma City VA Medical Center 3/2012-2024
2. ASGE Quality in Endoscopic Research Award: Use of Diphenhydramine as an Adjunctive Sedative for Colonoscopy in Patients Chronically on Opioids PI: Salman Nusrat Co-PI: William Tierney 5/2014-6/2015

Selected Publications:

Effect of hyoscine N-butylbromide on adenoma detection rate: Meta-analysis of randomized clinical trials
2015    Madhoun MF, Ali T, Tierney WM, Maple JT
Dig Endosc. 2015 Mar; 27(3):354-60. Epub 2014 Oct. 16. PMID:25115416
Adult Bowel Preparations for Colonoscopy
2015    Chisholm, S.S., Patel, A.M., Tierney, W.M., Madhoun, M.F.
Journal of the Oklahoma State Medical Association. 2015(Jul): 108:311-7
DCLK1 Is Detectable in Plasma of Patients with Barrett's Esophagus and Esophageal Adenocarcinoma
2015    Whorton J, Sureban SM, May R, Qu D, Lightfoot SA, Madhoun M, Johnson M, Tierney WM, Maple JT, Vega KJ, Houchen CW
Dig Dis Sci. 2015; 60(2):509-513. PMID:25283374
Colonoscopy versus capsule: sharing the spotlight
2015    Tierney WM
Gastroenterology 2015 May; 148(5):892-4. [Epub ahead of print] PMID: 25805420
Erratum to: The Impact of Chronic Opioid Use on Colonoscopy Outcomes.
2015    Nusrat S, Mahmood S, Bitar H, Tierney WM, Bielefeldt K, Madhoun MF
Dig Dis Sci. 2015 (Mar); 60:1016-23 PMID: 25986520
Endoscopic Papillary Large Balloon Dilation Reduces the Need for Mechanical Lithotripsy in Patients with Large Bile DuctStones: A Systematic Review and Meta-Analysis
2014    Madhoun MF, Wani S, Hong S, Tierney WM, Maple JT
Diagn Ther Endosc. 2014; 2014:309618. PMID:24729674
Fecal microbiota transplantation in the treatment of Clostridium difficile infections.
2014    Austin M, Mellow M, Tierney WM
Am J Med. 2014 Jun;127(6):479-83. EPUB 2014 Feb 26. PMID:24582877
Colonoscopy preparations: clearing things up
2014    Tierney WM
(invited editorial) Gastrointest Endosc. 2014 Sep; 80:492-4. PMID: 25127946
The diagnostic accuracy of 22-gauge and 25-gauge needles in endoscopic ultrasound-guided fine needle aspiration of solid pancreatic lesions: a meta-analysis.
2013    Madhoun MF, Wani SB, Rastogi A, Early D, Gaddam S, Tierney WM, Maple JT.
Endoscopy;45(2):86-92. PMID: 23307148
The impact of video recording colonoscopy on adenoma detection rates.
2012    Madhoun MF, Tierney WM.
Gastrointest Endosc.;75(1):127-33. PMID: 21963062
EUS core curriculum.
2012    ASGE Training Committee, DiMaio CJ, Mishra G, McHenry L, Adler DG, Coyle WJ, Dua K, DeGregorio B, Enestvedt BK, Lee LS, Mullady DK, Pais SA, Rajan E, Sedlack RE, Tierney WM, Faulx AL.
Gastrointest Endosc.;76(3):476-81. PMID: 22898403