Beverley Greenwood-Van Meerveld

Contact Information:
Beverley Greenwood-Van Meerveld



 

Greenwood-Van Meerveld, Beverley (HSC)
Director, Oklahoma Center for Neuroscience, Professor of Physiology

Department of:

College Of Medicine/Physiology -Professor of Physiology

Center of:

OK Center for Neurosciences -Director

Other Organization:

Veterans Affairs Medical Center -Career Scientist

Education:

University of Calgary, Canada   Alberta Heritage Postdoctoral Research Fellow   1986
University of Sheffield, U.K.   Ph.D. GI Neurophysiology   1983
University of Sheffield, U.K.   BSc. with Special Honors: Physiology   1980

Professional Interest/Expertise/Specializations:
Major Research Interests: My long-term research objective is to understand how the brain regulates the gastrointestinal (GI) tract. In one aspect of my research we are studying the neuroanatomical and neuropharmacological substrates involved in the interaction between visceral pain and anxiety. Specifically my research focuses on the mechanisms connecting anxiety and visceral (colonic) hypersensitivity and attempting to identify at least one potential neural substrate that might be involved in the central processing of visceral pain. From there we hope to identify a receptor mechanism within the neural substrate that mediates central processing of visceral pain. A longer term goal is to investigate how the neural substrate modulates visceral pain sensitivity within the larger neural pathway controlling anxiety and finally identify potential pharmacotherapeutic targets in the central processing pathway that mediates visceral pain. With the aid of behavioral, pharmacological and electrophysiological methods we are examining the following: 1. The brain-gut axis as it relates to Irritable Bowel Syndrome and anxiety 2. Role of amygdala-mediated mechanisms in the control of visceral and somatic pain 3. Importance of early life trauma on visceral and somatic pain in adulthood 4. Sex-related differences in the relationship between visceral pain and anxiety 5. Effect of chronic stress on the GI tract 6. Effect of aging on the GI tract In addition to our work on brain-gut interactions, we are investigating the effects of novel pharmacological approaches to treat GI disorders such as IBS, IBD and post-operative ileus.

Websites:

Oklahoma Center for Neuroscience

Research Projects:

Selected Publications:

Age-Associated Remodeling of the Intestinal Epithelial Barrier
2013    Tran L, Greenwood-Van Meerveld B.
J Gerontol A Biol Sci Med Sci. 68(9):1045-56.
The Effects of Early Life Adversity on Visceral Pain: Importance of Sex Differences.
2013    Chaloner A Greenwood-Van Meerveld B.
Frontiers in Neuroendocrinology (pending revisions)
Sexually Dimorphic Effects of Unpredictable Early Life Adversity on Visceral Sensitivity in a Rodent Model.
2013    Chaloner A, Greenwood-Van Meerveld B.
J Pain 4(3): 270-80
Comparison of age-dependent alterations in pain and behavior between rat strains.
2013    Chaloner A, Greenwood-Van Meerveld, B.
Journal of the American Aging Association 35: 1-10
Early life adversity as a risk factor for visceral pain in later life: Importance of Sex Differences.
2013    Chaloner A Greenwood-Van Meerveld B.
Frontiers in Neuroendocrinology 7:13
Importance of Epigenetic Mechanisms in Visceral Pain Induced by Chronic Water Avoidance Stress
2013    Tran, L, Chaloner A, Sawalha AH, Greenwood-Van Meerveld, B.
Pyschoneuroendocrinology 38:898-906
Genetic diversity contributes to abnormalities in pain behaviors between young and old rats
2013    Chaloner A, Greenwood-Van Meerveld, B.
Journal of the American Aging Association 35: 1-10
Differential effects of intravesical resiniferatoxin on excitability of bladder spinal neurons upon colon-bladder cross-sensitization.
2013    Malykhina AP, Qin C, Lei Q, Pan XQ, Greenwood-Van Meerveld, B. Foreman RD
Brain Research 1491:213-24
Differential effects of intravesical resiniferatoxin on excitability of bladder spinal neurons upon colon-bladder cross-sensitization.
2013    Malykhina AP, Qin C, Lei Q, Pan XQ, Greenwood-Van Meerveld, B. Foreman RD
Brain Research 1491:213-24.
Importance of Epigenetic Mechanisms in Stress-Induced Visceral Pain.
2012    Tran, L, Chaloner A and Greenwood-Van Meerveld, B.
Pyschoneuroendocrinology (in press).
Efficacy of Ipamorelin, a Novel Ghrelin Agonist on Gastric Dysmotility in Rodents.
2012    Greenwood-Van Meerveld B, Tyler K, Mohammadi E, Pietra C.
Journal of Exp. Pharmacology (in press).
The Role of the Bed Nucleus of the Stria Terminalis (BNST) in Stress-Induced Nociception.
2012    Tran L., Wiskur B., Greenwood-Van Meerveld B.
Am J Physiol;302(11):G1301-9.
Gut Permeability in Health and Disease: an Update.
2012    Camilleri M, Spiller R, Madsen, K Greenwood-Van Meerveld B and Verne N.
Neurogastroenterol. Motil. (Review) (in press)
Importance of Steroid Receptor Mediated Mechanisms in the Amygdala on Visceral Perception in a Spontaneously Anxious Rat.
2012    Johnson, A.C., Tran L., Schulkin J, Greenwood-Van Meerveld, B.
Neurogastroenterol. Motil. (Review) (in press)
Activation of Colonic Mucosal 5HT-4 Receptors Enhances Propulsive Motility and Inhibits Colonic Hypersensitivity.
2012    Hoffman JM, Onesmo B. Balemba, Johnson, A, Tyler K, Zhao Hong, Galligan, J, Greenwood-Van Meerveld B Mawe GM.
Gastroenterology (Epub)
Evidence of Abnormal Intestinal Function Related to Hypocupremia in a Rodent Model.
2012    Greenwood-Van Meerveld, B and Prodan, CI.
Neurogastroenterol. Motil. 24 (3):283-7, e112.doi
Amygdala Lateralization in the Mediates Pain and Anxiety Behaviors in the Rat.
2012    Tran, L and Greenwood-Van Meerveld, B.
Physiol. Behav. 105 (2): 371-5
Differential involvement of amygdala corticoid receptors in visceral hyperalgesia following acute and repeated stress.
2012    Myers, B and Greenwood-Van Meerveld, B.
Am. J. Physiol 302(2):G260-6
Altered Expression of Glucocorticoid and CRF Receptors in the Rat Central Amygdala in Response to Elevated Amygdala Corticosterone.
2012    Tran, L, and Greenwood-Van Meerveld, B.
Behavioral Brain Research. 16;234(2):380-385
Aging and gastrointestinal neuromuscular function: Insights from within and outside the gut. (Review).
   Bitar K, Greenwood-Van Meerveld, B., Saad R and Wiley, JW. (2011)
Neurogastroenterol. Motil. (Epub ahead of print)
Ghrelin and a target for gastrointestinal motility disorders.
   Kriesgsman M and Greenwood-Van Meerveld, B (2011)
Peptides ((Epub ahead of print)
Sex steroids increase visceral sensitivity through an amygdala-dependent mechanism in a rodent model.
   Myers, B., Schulkin J and Greenwood-Van Meerveld, B. (2011)
J.Pain. 12:486-94.