Ferenc Deák

Contact Information:
Ferenc Deák



 

Deak, Ferenc (HSC)
Assistant Professor

Department of:

College Of Medicine/Department of Geriatrics -Assistant Professor

Center of:

OK Center for Neurosciences -Member
Reynolds Oklahoma Center on Aging -Assistant Professor

Education:

Semmelweis University, School of Medicine, Budapest, Hungary   MD   1994
Semmelweis University, Budapest, Hungary   Ph.D. Neurophysiology   2000

Professional Interest/Expertise/Specializations:
With more than 5 million Americans presently diagnosed with dementia and with as many as 10 million additional 'baby boomers' at risk, the prevention of dementia is a pressing public health priority as its diagnosis is expected to triple in the next 50 years. Importantly, aging is the leading risk factor for a vast array of neurodegenerative disorders and dementia in the elderly. Yet, the mechanisms through which aging and other genetic and environmental factors interact to cause neuronal dysfunction in the brain are not well characterized. One of the major goals of my research is to investigate the mechanisms by which a specific combination of altered neuronal and synaptic proteins elicits functional impairment in hippocampal and cortical neurons. Combining studies on synaptic transmitter release and the major synaptic proteins essential for exocytosis and functional assays using cutting-edge electrophysiological methods to address this question is a truly innovative approach, which has enormous translational relevance. I am a neuroscientist investigating synaptic mechanisms of learning and memory and the effects of aging on synaptic communication with an array of state-of-the-art techniques. I began my studies on the physiology of the synapse and hippocampal neuronal function as a graduate student. In 2001 as a post-doctoral fellow I was a lead author on a highly cited paper in Science on the role of the major SNARE protein of synaptic vesicles synaptobrevin2 in synaptic release.

Websites:

OU Reynolds Center Web site

Research Projects:

Startup and Neurophysiology Support Reynolds Oklahoma Center on Aging

Selected Publications:

Age-related autoregulatory dysfunction and cerebromicrovascular injury in mice with angiotensin II-induced hypertension.
2013    3. Toth P, Tucsek Z, Sosnowska D, Gautam T, Mitschelen M, Tarantini S, Deák F, Koller A, Sonntag WE, Csiszar A, Ungvari Z.
J Cereb Blood Flow Metab. 2013 Aug 14. doi: 10.1038/jcbfm.2013.143. PMID: 23942363
Synergistic effects of hypertension and aging on cognitive function and hippocampal expression of genes involved in ß-amyloid generation and AD.
2013    2. Csiszar A, Tucsek Z, Toth P, Sosnowska D, Gautam T, Koller A, Deák F, Sonntag WE, Ungvari ZI.
Am J Physiol Heart Circ Physiol. 2013 Aug 16. DOI: 10.1152/ajpheart.00288.2013. PMID: 23955715
Differential stimulation of neurotrophin release by the biocompatible nano-material (carbon nanotube) in primary cultured neurons.
2013    4. Kim YG, Kim JW, Pyeon HJ, Hyun JK, Hwang JY, Choi SJ, Lee JY, Deák F, Kim HW, Lee YI.
J Biomater Appl. 2013 doi: 10.1177/0885328213481637. PMID: 23559662
Insulin-like growth factor-1 in CNS and cerebrovascular aging.
2013    Sonntag WE, Deák F, Ashpole N, Toth P, Csiszar A, Freeman W, Ungvari Z.
Front Aging Neurosci. Print: 2013 PMID: 23847531 PMCID: PMC3698444
Aging,Synaptic Dysfunction, and Insulin-Like Growth Factor (IGF)-1.
2012    Deák F, Sonntag WE
J Gerontol A Biol Sci Med Sci. 2012 67:611-25. PMID: 22503992. PMCID: PMC3348499.
Alpha-latrotoxin stimulates a novel pathway of Ca2+-dependent synaptic exocytosis independent of the classical synaptic fusion machinery.
2009    Deák F, Liu X, Khvotchev M, Li G, Kavalali ET, Sugita S, Südhof TC.
J Neurosci 2009 Jul 8; 29(27):8639-48. PMID:19587270. PMCID:2739239. NIHMS:133617.
Munc18-1 Binding to the Neuronal SNARE Complex Controls Synaptic Vesicle Priming.
2009    Deák F*, Xu Y*, Chang W, Dulubova I, Khvotchev M, Liu X, Südhof TC, Rizo J.
J Cell Biol. 2009 Mar 9;184(5):751-64. Epub 2009 Mar 2. PMID: 19255244. PMCID: PMC2686405.
Molecular substrates mediating lanthanide-evoked neurotransmitter release in central synapses.
2008    Chung C, Deák F, Kavalali ET
J Neurophysiol. 2008 Oct;100(4):2089-100. Epub 2008 Aug 20. PMID: 18715899. PMCID: PMC2576212.
Differential effects of SNAP-25 deletion on Ca2+ -dependent and Ca2+ -independent neurotransmission.
2007    Bronk P, Deak F, Wilson MC, Liu X, Sudhof TC, Kavalali ET.
J Neurophysiol. 2007 Aug;98(2):794-806. Epub 2007 Jun 6. PMID:17553942.
Rabphilin regulates SNARE-dependent re-priming of synaptic vesicles for fusion.
2006    Deák F, Shin O, Tang J, Hanson P, Ubach J, Jahn R, Rizo J, Kavalali ET, Südhof TC.
EMBO J. 2006 Jun 21;25(12):2856-66. Epub 2006 Jun 8. PMID: 16763567
Structural determinants of synaptobrevin 2 function in synaptic vesicle fusion.
2006    Deák F, Shin O, Kavalali ET, Südhof TC.
J Neurosci. 2006 Jun 21;26(25):6668-76. PMID: 16793874.
An isolated pool of vesicles recycles at rest and drives spontaneous neurotransmission.
2005    Sara Y*, Virmani T*, Deák F, Liu X, Kavalali ET.
Neuron. 2005 Feb 17;45(4):563-73. PMID: 15721242.
Synaptobrevin is essential for fast synaptic-vesicle endocytosis.
2004    Deák F, Schoch S, Liu X, Südhof TC, Kavalali ET
Nat Cell Biol. 2004 Nov;6(11):1102-8. Epub 2004 Oct 10. PMID: 15475946
SNARE function analyzed in synaptobrevin/VAMP knockout mice.
2001    4. Schoch S*, Deák F *, Konigstorfer A*, Mozhayeva M, Sara Y, Sudhof TC, Kavalali ET.
Science 2001 Nov 2; 294(5544):1117-22. PMID:11691998. *Equal contribution