Altaf Mohammed

Contact Information:
Altaf Mohammed



 

Mohammed, Altaf (HSC)
Faculty

Department of:

College Of Medicine/Department of Medicine -
College Of Medicine/Medicine Hematology/Oncology -Assistant Professor of Research

Center of:

Education:

Osmania University, India   MS - Microbiology  
Osmania University, India   Ph.D - Microbiology  

Professional Interest/Expertise/Specializations:
Pancreatic and Colorectal Cancers, Genomic Instability and Cancer Stem cells

Websites:

Research Projects:

Understanding the role of genomic instability associated cancer stem cells during progression of pancreatic cancer
Understanding role of EGFR in regulating the synthesis of core mucin synthesizing genes and mucins in pancreatic cancer
Major focus of the laboratory has been identification of molecular targets for pancreas and colon cancers; and develop selective molecules as effective chemopreventive agents and their regimens for chemoprevention of cancer using in-vitro and in-vivo (carcinogen-induced and transgenic) models
Establishing biomarkers (molecular targets) relevant to different stages of pancreatic carcinogenesis i.e., PanIN1, PanIN2, PanIN3 (carcinoma in-situ), and adenocarcinoma; utilizing these biomarkers as surrogate endpoints of the specific stages
Efforts are also underway to understand the relation between diabetes, aging and pancreatic cancer

Selected Publications:

Endogenous n-3 Polyunsaturated Fatty Acids delay progression of Pancreatic Ductal Adenocarcinoma in Fat-1.P48Cre/+-LSL-KrasG12D/+ mice
2012    Altaf Mohammed, Naveena B. Janakiram, Misty Brewer, Ashley Duff, Stan Lightfoot, Richard S. Brush, Robert E. Anderson and Chinthalapally V. Rao
Neoplasia
Atorvastatin delays progression of pancreatic lesions to carcinoma by regulating PI3/AKT signaling in p48(Cre/+) LSL-Kras(G12D/+) mice
2012    Altaf Mohammed, Naveena B. Janakiram, Li Qian, Stan Lightfoot, Vernon E. Steele and Chinthalapally V. Rao
Int J Cancer
Chemoprevention of Colon and SI tumorigenesis in APCMin/+ mice by Licofelone, A Novel Dual 5-LOX/COX inhibitor. Potential Implications for Human Colon Cancer Prevention.
2012    Altaf Mohammed, Naveena B. Janakiram, Li Qian, Chang-In-Choi, Yuting Zhang, Vernon E. Steele and Chinthalapally V. Rao
Cancer Prev Res
Pharmacokinetics and tissue and tumor exposure of CP-31398, a p53-stabilizing agent, in rats.
2012    Kapetanovic IM, Muzzio M, McCormick DL, Thompson TN, Johnson WD, Horn TL, Mohammed Altaf, Rao CV, Kopelovich L
Cancer Chemother Pharmacology
Lipoxygenase and Cyclooxygenase Pathways and Colorectal Cancer Prevention.
2012    Chinthalapally V. Rao, Naveena B. Janakiram and Altaf Mohammed
Curr Colorectal Cancer Rep
Chemopreventive effects of RXR-selective rexinoid bexarotene on intestinal neoplasia of Apc(Min/+) mice
2012    Naveena B. Janakiram, Altaf Mohammed, Li Qian, Chang-In-Choi, Vernon E. Steele and Rao C.V.
Neoplasia
Prophylactic Vaccine Approach for Colon and Pancreatic Cancers: Present and Future
2012    Naveena B. Janakiram, Altaf Mohammed, M.S. Bronze, Rao C.V.
Current Medicinal Chemistry
Inhibition of Pancreatic Intraepithelial Neoplasia Progression to Carcinoma by Nitric Oxide-Releasing Aspirin in p48(Cre/+) LSL-Kras(G12D/+) Mice
2012    Chinthalapally V. Rao, Altaf Mohammed, Naveena B. Janakiram, Qian Li, Rebekah L. Ritchie, Stan Lightfoot, Awasthi Vibhudutta and Vernon E. Steele
Neoplasia
Early Detection and Prevention of Pancreatic Cancer: Use of Genetically Engineered Mouse Models and advanced Imaging Technologies
2012    Altaf Mohammed, Naveena B. Janakiram, Stan Lightfoot, Hariprasad Gali, Vibhudutta Awasthi and Chinthalapally V. Rao
Current Medicinal Chemistry
DCAMKL-1 Regulates Epithelial-Mesenchymal Transition in Human Pancreatic Cells through a miR-200a-Dependent Mechanism.
2011    Sripathi M. Sureban, Randal May, Stan A. Lightfoot, Aimee B. Hoskins, Megan Lerner, Daniel J. Brackett, Russell G. Postier, Rama Ramanujam, Altaf Mohammed, Chinthalapally V. Rao, James H. Wyche, Shrikant Anant, and Courtney W. Houchen
Cancer Research
Role of lipoxins, resolvins and other bioactive lipids in colon and pancreatic cancer.
2011    Naveena B. Janakiram, Altaf Mohammed, Rao C.V.
Cancer Metastasis Reviews
The Epidermal Growth Factor Receptor Inhibitor Gefitinib in a Conditional LSL-KrasG12D/+ Transgenic Mouse Model Prevents the Progression of Pancreatic Lesions to Carcinoma.
2010    Altaf Mohammed, Naveena B. Janakiram, Qian Li, madka V, Ely M, Lightfoot Stan, Crawford H, Steele VE, Rao C.V.
Cancer Prev Res
Chemopreventive effects of Frondanol A5, a Cucumaria frondosa extract, against rat colon carcinogenesis and human colon cancer cell proliferation.
2010    Naveena B J, Altaf M, Yuting Zhang, Chang-In-Choi, Carl Woodward, Peter Collin, Steele V E and Rao CV
Cancer Prevention Research
Prevention and Treatment of Pancreatic Cancer by Curcumin in combination with Omega-3 fatty Acids.
2008    Malisetty V. Swamy, Bhargava Citineni, Jagan M.R. Patlolla, Altaf Mohammed, Yuting Zhang, and Chintalapally V. Rao
Nutrition and Cancer
ß-Ionone inhibits colonic aberrant crypt foci in rats, suppresses cell growth and induces retinoid X receptor ¿ in human colon cancer cells.
2008    Naveena, B.J., Indranie, C., Altaf, MD., Steele, V.E and Rao C.V.
Molecular Cancer Therapeutics