Wei Yue

Contact Information:
Wei Yue



 

Yue, Wei (HSC)
Assistant Professor

Department of:

College Of Pharmacy/Pharmaceutical Sciences -Assistant Professor

Center of:

Education:

Peking Union Medical College   PhD   2001
Sandong University   PhD   2001
Shandong University   MS   1998
Shandong Agricultural University   BS   1995

Professional Interest/Expertise/Specializations:
Hepatic Drug transport proteins are now recognized as important clinically-relevant determinants of variable drug responsiveness and unexpected drug-drug interactions (DDIs) Organic anion transporting polypeptides (OATPs) are major hepatic transport proteins that mediate the uptake, from blood into the liver, of a diverse array of endogenous compounds (e.g. bile acids), environmental toxins, and many drugs, including lipid-lowering statins, antibiotics, immunosuppressants, cardiac glycosides, andidiabetic and anticancer agents. Dysfunction of OATP1B1 and OATP1B3 is closely related with altered drug pharmacokinetics and toxicity. Genetic polymorphisms of OATP1B1 and OATP1B3 that have decreased transport function are associated with markedly increased plasma concentrations and systemic exposure of many drugs. Dr. Yue directs an NIH-funded research program focused on studying the role of drug transport proteins, including OATPs, in drug disposition, aiming to predict transporter-mediated drug-drug and drug-disease interactions and toxicities. Multi-disciplinary approaches are utilized in the Yue research program including: 1) characterization of drug-drug interactions and pharmacokinetics of drug transport using in vitro models (e.g. cultured rat and human hepatocytes, transporter-over expressing cell lines); 2) recombinant viral vector-mediated gene transfer and RNA interference (RNAi); 3) pharmacogenomic studies; and 4) contemporary molecular biology techniques.

Websites:

Research Projects:

Function and regulation of OATP1B1 and OATP1B3 (NIH/NIGMS R01)

Selected Publications:

Novel Mechanism of Impaired Function of Organic Anion Transporting Polypeptide (OSTP1B3) in Human Hepaticytes; Post-Translational Regulation of OAPT1B3 by Protein Kinsase C Activation
2014    Yue W
Drug Metabolism and Disposition 42: 1964-1970
Protein kinase C (PKC) activation rapidly down-regulates organic anion transporting polypeptide (OATP) 1B3 transport function in sandwich cultured primary human hepatocytes; a Novel mechanism of indirect drug-transport interaction
2014    Meng X, Kock K, Li J, Brouwer KLR and Yue W
Drug Metabolism and Disposition
Experimental approaches to evaluate the impact of impaired function of drug transporters on hepatobiliary disposition; case study with breast cancer resistance protein (Bcrp) and multidrug resisitance associated protein 2 (Mrp2) in sandwich cultured hepatocytes (SCH)
2014    Yang K, Pfeifer N, Hardwick R, Yue W, Stewart P, Brouwer KLR
Molecular Pharmaceutics
Up-regulation of organic anion transporting polypeptide (ATP)1B3 transport activity by proteasome inhibition.
2012    Li J; Snellings M; Yue W.
Drug Metabolism Reviews
1-dependent regulation of UCH L1 expression in B-lymphoma cells.
2011    Bheda A; Yue W; Gullapalli A; Shackelford J; Pagano JSP
Leukemia and Lymphoma
Differential disposition of chenodeoxycholic acid versus taurocholate acid in response to acute trolitazone exposure in rat hepatocytes.
2011    Marion TL; Perry CH; St Clair RL; Yue W; Brouwer KLR.
Toxicological Sciences
Decreased hepatic breast cancer resistance protein expression and function in multidrug resistance-associated protein 2-deficient TR rates.
2011    Yue W; Lee J; Abe K; Brouwer KLR
Drug Metabolism and Disposition
Regulation of organic anion transporting polypeptide (OATP)1B3 function by protein kinase C.
2010    Yue W; Kock K; Brouwer KLR.
AAPS Journal 2010
Novel Mechanism of Impaired Function of Organic Anion Transporting Polypeptide (OATP) 1B3 in Human Hepatocytes; Post-translational Regulation of OATP1B3 by Protein Kinase C Activation.
   Powell J, Farasyn, Kock K, Meng X, Pahwa S, Brouwer KLR and Yue W.
Drug Metabolism and Disposition, 2014, 42:1964-1970. PMID: 25200870
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