Rodney K. Tweten

Contact Information:
Rodney K. Tweten



 

Tweten, Rodney K. (HSC)
Professor

Department of:

College Of Medicine/Microbiology & Immunology -Professor

Center of:

Education:

Kansas State University   Ph. D.   1982

Professional Interest/Expertise/Specializations:
The focus of Dr. Tweten's research is on the molecular mechanism and cell biology of the cholesterol-dependent cytolysins (CDCs) and, more recently, the membrane attack complex/perforin (MACPF)-like proteins. The CDCs comprise a large family of toxins that contribute to the pathogenesis of a wide variety of Gram-positive bacterial pathogens. The MACPF proteins, which appear to be ancient relatives of CDCs, contribute to immune defense, pathogenesis of various eukaryotic pathogens and may be associated with developmental patterning processes. The study of the CDCs has revealed new paradigms in protein structure and function as well providing insights into their contribution to pathogenesis and the development of vaccine strategies.

Websites:

Microbiology Website, Dr. Tweten

Research Projects:

Selected Publications:

Mapping the intermedilysin-human CD59 receptor interface reveals a deep correspondence with the binding site on CD59 for complement binding proteins C8alpha and C9.
2011    Wickham, S. E., E. M. Hotze, A. J. Farrand, G. Polekhina, T. L. Nero, S. Tomlinson, M. W. Parker, and R. K. Tweten
The Journal of Biological Chemistry
http://www.jbc.org/content/286/23/20952.long
Only two amino acids are essential for cytolytic toxin recognition of cholesterol at the membrane surface.
2010    Farrand AJ, Lachapelle S, Hotze EM, Johnson AE, & Tweten RK
Proc Natl Acad Sci
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2840085/?tool=pubmed
Intermedilysin-receptor interactions during assembly of the pore complex: assembly intermediates increase host cell susceptibility to complement-mediated lysis
2009    LaChapelle S, Tweten RK, & Hotze EM
The Journal of Biological Chemistry
http://www.jbc.org/content/284/19/12719.long
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