Guangpu Li

Contact Information:
Guangpu Li


Li, Guangpu (HSC)

Department of:

College Of Medicine/Biochemistry & Molec Biology -Professor

Center of:


Washington University, St. Louis, MO   Ph.D.   1991

Professional Interest/Expertise/Specializations:
Endocytosis/endosome fusion: molecular mechanism and function in signal transduction and regulation of cell growth and differentiation Cells are basic building blocks of living organisms. Endocytosis is a fundamental cellular process for uptake of nutrients, regulation of cell surface receptors, and maintenance of cell homeostasis. While it is an important cellular function, endocytosis is often employed by microorganisms like viruses for entry and infection of cells. Our research is directed towards understanding the molecular basis of endocytosis and its role in regulation of cell growth and differentiation, which may provide valuable knowledge on how this cellular process is involved in human diseases such as cancer and infectious diseases and whether endocytosis can be targeted to develop therapeutics. Current projects include (1) mechanism of Rab5-regulated endosome fusion, which is a critical step during endocytosis and (2) Role of endocytosis in nerve growth factor (NGF)-mediated signal transduction and neuron differentiation. We hope to describe endocytosis/endosome fusion in molecular terms and identify regulatory mechanisms that control the activity of these cellular processes during cell growth and differentiation.


Research Projects:

Selected Publications:

Rab22 controls NGF signaling and neurite outgrowth in PC12 cells.
   Wang, L., Liang, Z., and Li, G.
Mol Biol Cell
Rab GTPases, membrane trafficking and diseases.
   Li, G
Curr Drug Targets
Delayed onset of positive feedback activation of Rab5 by Rabex-5 and Rabaptin-5 in endocytosis.
   Zhu H, Qian H, and Li G
Rabex-5 is a Rab22 effector and mediates a Rab22-Rab5 signaling cascade in endocytosis.
   Zhu, H, Liang, Z. and Li, G
Mol Biol Cell
Rabaptin-5-independent Membrane Targeting and Rab5 Activation by Rabex-5.
   Zhu, H., Zhu, G., Liu, J., Liang, Z., Zhang, X.C., and Li, G
Mol Biol Cell
GTP hydrolysis mechanism of Ras-like GTPases.
   Li, G and Zhang, X.C.
J Mol Biol
Nerve Growth Factor-mediated Neurite Outgrowth via Regulation of Rab5.
   Liu, J., Lamb D., Chou, M., Liu, Y-J., Li, G.
Mol Biol Cell
Recombinant Sindbis virus expressing functional GFP in the nonstructural protein nsP3.
   Liang, Z. and Li, G.
Gene Therapy & Mol Bio
Structural basis of Rab5-Rabaptin% interaction in endocytosis.
   Zhu, G., Zhai, P., Liu, J., Terzyan, S., Li, G., and Zhang, X.C.
Nature Struc & Mol Biol
Crystal structure of human GGA1 GAT domain complexed with the GAT-binding domain of Rabaptin5.
   Zhu, G., Zhai, P., He, X., Wakeham, N., Rodgers, K., Li, G., Tang, J., and Zhang, X.C.
Structure of the APPL1 BAR-PH domain and characterization of its interaction with Rab5.
   Zhu, G., Chen, J., Liu, J., Brunzelle, J.S., Huang, B. Wakeham, N. Terzyan, S., Li, X., Rao, Z., Li, G. and Zhang, X.C.