James J. Tomasek

Contact Information:
James J. Tomasek



 

Tomasek, James J. (HSC)
Professor

Department of:

College Of Medicine/Cell Biology -Professor

Center of:

Education:

State University of New York at Albany   PhD  

Professional Interest/Expertise/Specializations:
The major goal of my laboratory is to elucidate the cellular and molecular mechanisms that control wound healing and pathologic contractures. The unifying feature of these studies is to understand the interplay between actin isoforms, actin dynamics, and the mechanical environment in regulating myofibroblast formation and function. Current studies examine the role of different actin isoforms in contractile force generation and how mechanical forces regulate gene expression of cytoskeletal proteins through actin dynamics and the myocardin related transcription factors. These studies involve transgenic and knockout mouse models, in vitro models to measure and regulate force generation, and molecular techniques to study gene regulation.

Websites:

Research Projects:

Selected Publications:

Myocardin-related transcription factors A and B are key regulators of TGF-beta1-induced fibroblast to myofibroblast differentiation.
2011    Crider, B.J., Risinger, G.M., Haaksma, C.J., Howard, E.W., and Tomasek, J.J.

Myoepithelial cell contraction and milk ejection are impaired in mammary glands of mice lacking smooth muscle alpha-actin.
2011    Haaksma, C.J., Schwartz, R.J., and Tomasek, J.J.

Matrix metalloproteinase inhibition delays wound contraction through attenuated transforming growth factor-beta1 activation.
2010    Mirastschiski, U., Schnabel, R., Claes, J., Schneider, W., Agren, M.S., Haaksma, C.J. and Tomasek, J.J.

Regulation of Smooth Muscle alpha-Actin Expression in Granulation Tissue Myofibroblasts is Dependent on the Intronic CArG Element and the Transforming Growth Factor beta-1 Control Element.
2005    Tomasek, J.J., McRae, J., Owens, G.K., and Haaksma, C.J.

Myofibroblasts and mechano-regulation of connective tissue remodeling.
2002    Tomasek, J.J., Gabbiani, G., Hinz B., Chaponnier C., and Brown, R.A.