James F. McGinnis

Contact Information:
James F. McGinnis



 

McGinnis, James F. (HSC)
Professor

Department of:

College Of Medicine/Cell Biology -Professor
College Of Medicine/Ophthalmology -Professor

Center of:

OK Center for Neurosciences -Associate Director of Student Affairs

Education:

State University of New York at Buffalo   PhD  

Professional Interest/Expertise/Specializations:
I have been the Director of the NEI/DMEI Image Module and the COBRE Image Core for the past 13 years. I am a Professor in the Departments of Ophthalmology and Cell Biology, an NEI R01-funded investigator and Associate Director of the Oklahoma Center for Neuroscience. The overarching objective of my research program is to prevent vision loss using prophylactic and therapeutic agents, and determining the molecular mechanisms by which they act. I think that the excessive increase in toxic Reactive Oxygen Species (ROS) is an ¿Achille¿s Heel¿ for inherited retinal degeneration, Diabetic Retinopathy, Age related Macular Degeneration (AMD) and other neurodegenerative diseases and that by targeting excess ROS for destruction, the downstream damage and disease symptoms can be prevented and/or decreased, vision can be prolonged and the quality of life for such patients dramatically improved. Consistent with this idea, I have developed a research program using rodent models to demonstrate the positive effects of the use of catalytic antioxidant cerium oxide nanoparticles or nanoceria to inhibit pathologic neovascularization and retinal degeneration.

Websites:

Research Projects:

Selected Publications:

Nanoceria extend photoreceptor cell lifespan in tubby mice by modulation of apoptosis/survival signaling pathways.
2011    Kong, L., Cai, X., Zhou, X., Wong, L. L., Karakoti, A. S., Seal, S., & McGinnis, J. F.

Nanoceria Inhibit the Development and Promote the Regression of Pathologic Retinal Neovascularization in the Vldlr knockout mouse.
2011    Zhou, X., Wong, L.L. (co-first author), Karakoti, A.S., Seal, S., and McGinnis, J.F.

Neuroprotective effect of overexpression of thioredoxin on photoreceptor degeneration in Tubby mice.
2010    Kong, L., Zhou, X., Li, F., Yodoi, J., McGINNIS, J.F. and Cao, W.

Rare Earth Nanoparticles Prevent Retinal Degeneration Induced by Intracellular Peroxides.
2006    Chen, J., Patil, S., Seal, S. and McGINNIS, J.F.

Bright Cyclic Light Accelerates Photoreceptor Cell Degeneration in Tubby Mice. Neurobiology of Disease
2006    Kong, L., Li, K., Soliman, C., Li, S., Elias, R.V., Zhou, X., Lewis, D.A., McGINNIS, J.F. and Cao W.