Ralf G Janknecht

Contact Information:
Ralf G Janknecht


Janknecht, Ralf G. (HSC)
Assistant Professor

Department of:

College Of Medicine/Cell Biology -Assistant Professor

Center of:

Peggy & Charles Stephenson Oklahoma Cancer Center -


Univeristy of Bochum, Germany   PhD   1990

Professional Interest/Expertise/Specializations:
Our laboratory is interested in understanding how dysregulation of gene transcription leads to cancer. In particular, we focus on ETS transcription factors and JMJD histone demethylases. To this end, we study those proteins with biochemical and cell biological methods and also analyze respective transgenic and knock-out mouse models. Currently, our research is mostly focused on prostate cancer, but we also have interests in other tumors such as those of the breast and colon. Finally, we attempt to develop small molecule inhibitors for JMJD histone demethylases.


Research Projects:

Selected Publications:

Histone demethylase JARID1B/KDM5B is a corepressor of TIEG1/KLF10.
2010    Kim, J., Shin, S., Subramaniam, M., Bruinsma, E., Kim, T.-D., Hawse, J. R., Spelsberg, T. C. and Janknecht, R.

Pleiotropic effects of p300-mediated acetylation on p68 and p72 RNA helicase.
2010    Mooney, S. M., Goel, A., D¿Assoro, A. B., Salisbury, J. L. and Janknecht, R.

Sumoylation of p68 and p72 RNA helicases affects protein stability and transactivation potential.
2010    Mooney, S. M., Grande, J. P., Salisbury, J. L. and Janknecht, R.

Induction of prostatic intraepithelial neoplasia and modulation of androgen receptor by ETS variant 1/ETS-related protein 81.
2009    Shin, S., Kim, T.-D., Jin, F., van Deursen, J. M., Dehm, S. M., Tindall, D. J., Grande, J. P., Munz, J.-M., Vasmatzis, G. and Janknecht, R.

Rcl is a novel ETV1/ER81 target gene upregulated in breast cancer.
2008    Shin, S., Bosc, D. G., Ingle, J. N., Spelsberg, T. C. and Janknecht, R.