William E Sonntag

Contact Information:
William E Sonntag


Sonntag, William E. (HSC)

Department of:

College Of Medicine/Department of Geriatrics -Professor

Center of:

OK Center for Neurosciences -Professor
Reynolds Oklahoma Center on Aging -Director and Donald W. Reynolds Endowed Chair of Aging Research


Tulane University, New Orleans, Louisiana   PhD   1979

Professional Interest/Expertise/Specializations:
Aging, brain aging, vascular cognitive impairment, IGF-1, growth hormone, radiation induced cognitive impairment, depression


Reynolds Oklahoma Center on Aging

Research Projects:

Effects of whole brain radiation on vascualr and cognitive function
Effects of endocrine and paracrine IGF-1 deficiency on the genesis of mild cognitive impairment with age
Early life hypothalamic growth hormone and IGF-1 deficiency on aging
IGF-1 deficiency and late-lfe depression

Selected Publications:

Role of 20-HETE,TRP channels & BKCa in dysregulation of pressure-induced Ca2+ signaling and myogenic constriction of cerebral arteries in aged hypertensive mice.
2013    Toth P, Csiszar A, Tucsek Z, Sosnowska D, Gautam T, Koller A, Laniado Schwartzman M, Sonntag WE, Ungvari ZI.
Am J Physiol Heart Circ Physiol. 2013 Oct 4. [Epub ahead of print]
Increased hippocampal NgR1 signaling machinery in aged rats with deficits of spatial cognition.
2013    VanGuilder Starkey HD, Sonntag WE, Freeman WM.
Eur J Neurosci. 2013 May;37(10):1643-58. doi: 10.1111/ejn.12165. Epub 2013 Feb 26.
Expression of NgR1-antagonizing proteins decreases with aging and cognitive decline in rat hippocampus.
2013    VanGuilder Starkey HD, Bixler GV, Sonntag WE, Freeman WM.
Cell Mol Neurobiol. 2013 May;33(4):483-8. doi: 10.1007/s10571-013-9929-4. Epub 2013 Mar 24.
Ionizing radiation promotes the acquisition of a senescence-associated secretory phenotype and impairs angiogenic capacity in cerebromicrovascular endothelial cells: role of increased DNA damage and decreased DNA repair capacity in microvascular radiosensitivity.
2013    Ungvari Z, Podlutsky A, Sosnowska D, Tucsek Z, Toth P, Deak F, Gautam T, Csiszar A, Sonntag WE.
J Gerontol A Biol Sci Med Sci. 2013 Dec;68(12):1443-57. doi: 10.1093/gerona/glt057. Epub 2013 May 20.
Insulin-like growth factor-1 in CNS and cerebrovascular aging.
2013    Sonntag WE, Deak F, Ashpole N, Toth P, Csiszar A, Freeman W, Ungvari Z.
Front Aging Neurosci. 2013 Jul 2;5:27. doi: 10.3389/fnagi.2013.00027. eCollection 2013.
Age-related autoregulatory dysfunction and cerebromicrovascular injury in mice with angiotensin II-induced hypertension.
2013    Toth P, Tucsek Z, Sosnowska D, Gautam T, Mitschelen M, Tarantini S, Deak F, Koller A, Sonntag WE, Csiszar A, Ungvari Z.
J Cereb Blood Flow Metab. 2013 Nov;33(11):1732-42. doi: 10.1038/jcbfm.2013.143. Epub 2013 Aug 14.
Synergistic effects of hypertension and aging on cognitive function and hippocampal expression of genes involved in ß-amyloid generation and Alzheimer's disease.
2013    Csiszar A, Tucsek Z, Toth P, Sosnowska D, Gautam T, Koller A, Deak F, Sonntag WE, Ungvari Z.
Am J Physiol Heart Circ Physiol. 2013 Oct;305(8):H1120-30. doi: 10.1152/ajpheart.00288.2013. Epub 2013 Aug 16.
Impaired Vascular Endothelial Growth Factor A and Inflammation in Patients With Peripheral Artery Disease.
2013    Gardner AW, Parker DE, Montgomery PS, Sosnowska D, Casanegra AI, Esponda OL, Ungvari Z, Csiszar A, Sonntag WE.
Angiology. 2013 Sep 3. [Epub ahead of print]
Whole Brain Radiation-Induced Vascular Cognitive Impairment: Mechanisms and Implications.
2013    Warrington JP, Ashpole N, Csiszar A, Lee YW, Ungvari Z, Sonntag WE.
J Vasc Res. 2013 Oct 1;50(6):445-457. [Epub ahead of print] PMID: 24107797
Aging-induced dysregulation of dicer1-dependent microRNA expression impairs angiogenic capacity of rat cerebromicrovascular endothelial cells.
2012    Ungvari Z, Tucsek Z, Sosnowska D, Toth P, Gautam T, Podlutsky A, Csiszar A, Losonczy G, Valcarcel-Ares MN, Sonntag WE, Csiszar A
J Gerontol A Biol Sci Med Sci. 2013 Aug;68(8):877-91. doi: 10.1093/gerona/gls242. Epub 2012 Dec 13.
Liver-specific knockdown of IGF-1 decreases vascular oxidative stress resistance by impairing the Nrf2-dependent antioxidant response: a novel model of vascular aging.
2012    Bailey-Downs LC, Mitschelen M, Sosnowska D, Toth P, Pinto JT, Ballabh P, Valcarcel-Ares MN, Farley J, Koller A, Henthorn JC, Bass C, Sonntag WE, Ungvari Z, Csiszar A.
Gerontol A Biol Sci Med Sci.
Age-Associated Proinflammatory Secretory Phenotype in Vascular Smooth Muscle Cells From the Non-human Primate Macaca mulatta: Reversal by Resveratrol Treatment.
2012    Csiszar A, Sosnowska D, Wang M, Lakatta EG, Sonntag WE, Ungvari Z.
Gerontol A Biol Sci Med Sci.
Disruption of Nrf2 Signaling Impairs Angiogenic Capacity of Endothelial Cells: Implications for Microvascular Aging.
2012    Valcarcel-Ares MN, Gautam T, Warrington JP, Bailey-Downs L, Sosnowska D, de Cabo R, Losonczy G, Sonntag WE, Ungvari Z, Csiszar A.
Gerontol A Biol Sci Med Sci.
Hippocampal expression of myelin-associated inhibitors is induced with age-related cognitive decline and correlates with deficits of spatial learning and memory.
2012    Vanguilder HD, Bixler GV, Sonntag WE, Freeman WM.
J Neurochem
Whole brain radiation-induced impairments in learning and memory are time-sensitive and reversible by systemic hypoxia.
2012    Warrington JP, Csiszar A, Mitschelen M, Lee YW, Sonntag WE.
PLoS One
Aging, Synaptic Dysfunction, and Insulin-Like Growth Factor (IGF)-1.
2012    Deak F, Sonntag WE.
Gerontol A Biol Sci Med Sci.
Diverse Roles of Growth Hormone and Insulin-Like Growth Factor-1 in Mammalian Aging: Progress and Controversies.
2012    Sonntag WE, Csiszar A, Decabo R, Ferrucci L, Ungvari Z.
Gerontol A Biol Sci Med Sci.