Xi-Qin Ding

Contact Information:
Xi-Qin Ding



 

Ding, Xi-Qin (HSC)
Assistant Professor

Department of:

College Of Medicine/Cell Biology -Assistant Professor

Center of:

Education:

Lund University   PhD   1997

Professional Interest/Expertise/Specializations:
My laboratory investigates retinal degeneration, with a particular interest in cone photoreceptor degeneration in cyclic nucleotide-gated (CNG) channel deficiency. Cone phototransduction mediated by photoreceptor CNG channel activation is essential for central and color vision and visual acuity. Mutations in the channel subunits CNGA3 and CNGB3 are highly linked to various forms of cone diseases, including achromatopsia, progressive cone dystrophy, and some maculopathies. We study the retinal pathogenesis and mechanism of cone degeneration in CNG channel deficiency using morphological, biochemical, and molecular biological approaches and a variety of mouse models. We are also interested in determining the mechanism of retinal degeneration resulting from deficiency of other components of the phototransduction cascade. This includes deficiency of photoreceptor phosphodiesterase and guanylate cyclase. The ultimate goal of our research is to determine the mechanism of photoreceptor degeneration in hereditary retinal diseases in order to develop therapeutic strategies and interventions.

Websites:

Research Projects:

Selected Publications:

Long-term and age-dependent restoration of visual function in a mouse model of CNGB3-associated achromatopsia following gene therapy.
2011    Livia S Carvalho, Jianhua Xu, Rachael A Pearson, Alexander J Smith, James W Bainbridge, Lynsie M Morris, Steven J Fliesler, Xi-Qin Ding and Robin R Ali

Early Onset, Slow Progression of Cone Photoreceptor Dysfunction and Degeneration in CNG Channel Subunit CNGB3 Deficiency.
2011    Jianhua Xu, Lynsie Morris, Steven J. Fliesler, David M. Sherry, and Xi-Qin Ding

The Disease-Causing Mutations in the Carboxyl-Terminus of Cone Cyclic Nucleotide-Gated Channel CNGA3 Subunit Alter the Local Secondary Structure and Interfere with the Channel Active Conformational Change.
2010    Alexander V. Matveev, J. Browning Fitzgerald, Jianhua Xu, Anna P. Malykhina, Karla K. Rodgers, and Xi-Qin Ding

Impaired Cone Function and Cone Degeneration Resulting from CNGB3 Deficiency: Down-regulation of CNGA3 Biosynthesis as a Potential Mechanism.
2009    Xi-Qin Ding, Cynthia S. Harry, Umino Y, Alexander V. Matveev, Steven J. Fliesler and Robert B. Barlow

Native Cone Photoreceptor Cyclic Nucleotide-Gated Channel Is A Heterotetrameric Complex Comprising both CNGA3 and CNGB3: A Study Using the Cone-Dominant Retina of Nrl-/- Mice.
2008    Alexander V. Matveev, Alexander B. Quiambao, J. Browning Fitzgerald and Xi-Qin Ding