Yun Z. Le

Contact Information:
Yun Z. Le


Le, Yun Z. (HSC)

Department of:

College Of Medicine/Medicine - Endocrinology -Associate Professor

Center of:

Harold Hamm Diabetes Center -


Dalhousie University, Canada   PhD   1994

Professional Interest/Expertise/Specializations:


Research Projects:

Selected Publications:

Conditional knockdown of DNA methyltransferase-1 (Dnmt1) reveals a key role of retinal pigment epithelium integrity in photoreceptor outer segment morphogenesis.
2013    Nasonkin I.O., Merbs S.L., Lazo K., Oliver V.F., Brooks M., Patel K., Enke R.A., Nellissery J., Jamrich M., Le Y., Bharti K., Fariss R.N., Rachel R.A., Zack D.J., Rodriguez-Boulan E.J., Swaroop R.
Development 140: 1330-41. PMC3585665.
Photoreceptor Avascular Privilege is shielded by soluble VEGF receptor-1.
2013    Luo L., Uehara H., Olsen T., Das K.S., Zhang X., Simonis J.M, Jackman K., Archer B., Singh N., Miya T., Huang W., Ahmed F., Liu Y., Ambati J., Mamalis C., Chiodo V.A., Hauswirth W.W., Ferrara N., Baffi J., Gao G., Zygmunt K. Whitaker R., Lacal P.M., Orecchia A., Fu Y., Le Y., Jones A.D., Owen L., Holt D., Albuquerque R., Baehr W., Thomas K., Li D., Chalam K.C., Shibuya. M., Grisanti S., Wilson
eLife 2:e00324 (doi: 10.7554/eLife.00324). PMC3687373
Autophagy protects the retina from light-induced degeneration.
2013    Chen Y., Yu Sawada O., Kohno H., Le Y., Subauste C., Maeda T., Maeda A.
J. Biol. Chem. 288: 7506-18. PMC3597791
X-box binding protein 1 is essential for the anti-oxidant defense and cell survival in the retinal pigment epithelium.
2012    Zhong Y., Li J. Wang, J.J., Chen C., Tran JT, Saadi A, Yu Q, Le Y., Mandal N.A. Anderson R.E., Zhang S.X.
PLoS One 7(6):e38616. PMC3371004
Suppression of Retinal Neovascularization by Lentivirus- Mediated Netrin-1 Small Hairpin RNA.
2012    Xu H., Liu J., Xiong S. Le Y., Xia X.
Ophthalmic Res 47:163-169 (DOI:10.1159/000331428). PMC3251241.
Presence of RPE-produced VEGF in a timely manner is critical to choroidal vascular development.
2012    Zhu, M., Bai, Y., Zheng, L. *Le, Y.
Adv Exp Med Biol. 723:299-304. PMID:22183346
Impacts of Hypoxia-inducible Factor-1 Knockout in the Retinal Pigment Epithelium (RPE) on Choroidal Neovascularization.
2012    Lin M., Hu Y., Chen Y., Zhou K., Jin J., Zhu M., Le Y., Ge J., Ma J.X.
Invest. Ophthalmol. Vis. Sci. 53:6197¿6206
Optional code and disease map for adult retinal cell types.
2012    Siegert S., Cabuy E., Scherf B.G., Kohler H., Panda S., Le Y., Fehling H.J., Gaidatzis D., Stadler M.B., Roska B.
Nat Neurosci. 15:487-95. (doi: 10.1038/nn.3032). PMID:22267162.
RPE barrier breakdown in diabetic retinopathy: seeing is believing.
2012    Xu H., Song Z., Fu S., Zhu M., *Le Y.
J. Ocular Biology, Diseases and Informatics 4:83¿92. (DOI 10.1007/s12177-011-9068-4). PMC3342408
IFT20 is required for opsin trafficking and photoreceptor outer segment development.
2011    Keady B., Le Y., Pazour, G
Mol. Biol. Cells 22: 921-30. PMC3069017
Conditional gene targeting: dissecting the cellular mechanisms of retinal degenerations
2011    *Le Y.
J. Ophthalmol. (doi:10.1155/2011/806783). PMC3021885
The role of retinal Müller cell-derived hypoxia-inducible factor-1 in retinal inflammation and neovascularization in diabetic retinopathy.
2011    Lin M., Chen Y., Jin J., Hu Y., Zhou K., Zhu, M., Le Y., Ge J., Ma J.X.
Diabetologia 54:1554-66
Effect of Brimonidine on Retinal and Choroidal Neovascularization in Animal Models of Age-Related Macular Degeneration and Retinopathy of Prematurity.
2011    *Kusari J. (co-corresponding author), Padillo E.U., Zhou S., Ni M., Lalwani K., Bai Y. Wang J., Song, Z. Zhu M. *Le Y. (co-corresponding author), Gil D.W.
Invest. Ophthalmol. Vis. Sci. 52:5424-31. PMC3176033
Intravitreous high expression level of netrin-1 in patients with proliferative diabetic retinopathy.
2011    Liu J., Xia X., Xiong S. Le Y., Xu H.
Eye Science (Yan Ke Xue Bao) 26 (2):35-42. NIHMSID # 391961. PMC3445338.
Deletion of the p85¿ Regulatory Subunit of Phosphoinositide 3-Kinase in Cone Photoreceptor Cells Results in Cone Photoreceptor Degeneration.
2011    Ivanovic I., Anderson R.E., Le Y., Fliesler S., Sherry D., Rajala R.
Invest. Ophthalmol. Vis. Sci. 52:3775-83. PMC3109053.
Normoxic activation of hypoxia inducible factors in photoreceptors provides transient protection against light induced retinal degeneration Invest.
2011    Lange C., Heynen S., Tanimoto, N., Le Y., Meneau I., Seeliger M.W., Samardzija M., Grimm C.
Ophthalmol. Vis. Sci. 52:5872-80
Phosphoinositide 3-Kinase Signaling in Retinal Rod Photoreceptors.
2011    Ivanovic I., Rajala A., Gupta V., Dighe R., Le Y., Anderson R.E., Rajala R.
Invest. Ophthalmol. Vis. Sci. 52:6355-62. PMC3176013
Visualizing diabetes- and ischemia-induced breakdown of outer blood-retina barrier
2011    Xu H., *Le Y.
Invest. Ophthalmol. Vis. Sci. 52:2160-4. PMC3080181
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