Robert E. Anderson

Contact Information:
Robert E. Anderson



 

Anderson, Robert E. (HSC)
Professor

Department of:

College Of Medicine/Cell Biology -Professor
College Of Medicine/Ophthalmology -Professor

Center of:

OK Center for Neurosciences -Member

Education:

Texas A & M University, College Station, TX   PhD Biochemistry   1968
Baylor College of Medicine, Houston, TX   MD   1975
Texas A & M University, College Station, TX,   BA Mathematics   1963
Texas A & M University, College Station, TX,   MS Biochemistry   1965

Professional Interest/Expertise/Specializations:
Our research focuses on the metabolic pathways that (1) provide molecules essential for the normal function of the retina and (2) protect against stress-induced retinal degenerations. Disruptions in the former, which occurs in dominantly inherited Stargardt Macular Dystrophy (STGD3), leads to macular degeneration in children. We recently discovered that a unique group of fatty acids found primarily in photoreceptor membranes is greatly reduced in retinas of an animal model of STGD3. Current studies are focused on finding ways to deliver these essential fatty acids to the retina with the goal of preventing the retinas from degenerating. Environmental and hereditary stresses can lead to retinal degeneration. We discovered that the insulin receptor can be activated by light and initiate a series of ┬┐downstream┬┐ reactions that can protect the retina from light stress-induced degeneration. Current studies are focused on finding ways to fortify these pathways so that the retinas of persons susceptible to retinal diseases become more resistant to stress-induced degeneration. Finally, we have identified a number of synthetic and naturally occurring compounds that can protect the retina from oxidant stress-induced degeneration. Current research focuses on identifying the specific metabolic pathways these compounds affect and to test their efficacy in animal models of human age-related macular degeneration.

Websites:

Research Projects:

NIH COBRE P20-RR17703-06/10: Mentoring Vision Research in Oklahoma
NIH R01 EY04149-28/32: Lipid Metabolism in the Retina.
NIH P30 EY021725-01/05: Core Grant for Vision Research.
Beckman Institute for Macular Research. PBN derivatives for the treatment of atrophic macular degeneration

Selected Publications:

Deficiency of X-box binding protein 1 induces oxidative damage of the RPE: implications in age-related retinal degeneration.
2012    Zhong, Y., Li, J., Wang, J.J., Chen, C., Mandal, M.N.A., Yu, Q., Le, Y.Z., Anderson, R.E., and Zhang, S.X.
PLoS ONE
Natural compounds in retinal diseases.
2012    Yu , M., Anderson, R.E., and Mandal, N.A.
. R.D. Stratton et al. (eds.), Oxidative Stress in Applied Basic Research and Clinical Practice, Springer Science+Business Media, LLC. Pp. 437-456.
Intravitreal injection of erythropoietin glycosylation analogs does not protect rod photoreceptor cells from light-induced damage.
2012    Tanito M, Li F, Anderson RE
Adv Exp Med Biol.
Endogenous n-3 polyunsaturated fatty acids delay progression of pancreatic ductal adenocarcinoma in fat-1-p48(Cre/+)-LSL-Kras(G12D/+) mice.
2012    277. Mohammed A, Janakiram NB, Brewer M, Duff A, Lightfoot S, Brush RS, Anderson RE, Rao CV
Neoplasia 14:1249-59.
ELOVL4 protein preferentially elongates 20:5n3 to very long chain polyunsaturated fatty acids over 20:4n6 and 22:6n3.
2011    Yu, M, Benham, A, Logan, S, Brush, RS, Mandal, NA, Anderson, RE, and Agbaga, M-P.
J. Lipid Res.
PBN (a-phenyl-N-tert-butyl nitrone) prevents light-induced degeneration of the retina by Inhibiting RPE65 isomerohydrolase activity.
2011    Mandal, Md N.A., Moiseyev, G.P., Elliott1, M.H., Kasus-Jacobi, A., Li, X., Chen, H., Zheng, L., Nikolaeva, O., Floyd, R.A, Ma, J-x., Anderson, R.E.
J. Biol. Chem.
Phosphoinositide 3-kinase signaling in retinal rod photoreceptor functions.
2011    Ivanovic, I., Rajala, A., Gupta, V.K., Anderson, R.E, and Rajala, R.V.S.
Invest Ophthalmol Vis Sci.
Caffeic acid phenethyl ester protects 661W cells from H(2)O(2)-mediated cell death and enhances electroretinography response in dim-reared albino rats.
   Chen H, Tran JT, Anderson RE, Mandal MN
Mol Vis. 18:325-38. Epub 2012 May 30.