Leonidas Tsiokas

Contact Information:
Leonidas Tsiokas



 

Tsiokas, Leonidas (HSC)
Professor

Department of:

College Of Medicine/Cell Biology -Associate Professor

Center of:

OK Center for Neurosciences -Member

Education:

University of Medicine and Dentistry   PhD  

Professional Interest/Expertise/Specializations:
Molecular and cellular basis of Autosomal Dominant Polycystic Kidney Disease Autosomal dominant polycystic kidney disease (ADPKD) is one of the most common genetic diseases affecting more than half a million Americans and 12.5 million people, worldwide. It belongs to a group of pathological conditions called "ciliopathies" as they all seem to arise from defects in the assembly and/or function of the cilium, an antenna-like organelle protruding from the cell surface. Cilia are sensory organelles homing a large number of ion channels and receptors. Mutations in two genes, PKD1 and PKD2 are responsible for ADPKD. Their protein products, originally called PKD1 and PKD2 or polycystin-1 and 2 (currently named, TRPP2), respectively, are plasma membrane-spanning proteins present also in the primary cilium. It has been speculated that PKD1 and TRPP2 assemble into a receptor-channel complex linking extracellular stimuli to Ca2+ signaling. However, there are four major, yet unresolved questions that form the focus of our research interests: 1) what is the nature of the extracellular stimuli that activate the PKD1/TRPP2 receptor/channel complex? 2) How activation of PKD1 leads to the activation of TRPP2? 3) What are the downstream effectors of the PKD1/TRPP2 complex? 4) What is the role of the primary cilium in PKD2/TRPP2-based signaling? These questions are being investigated using complementary approaches in cell culture and the mouse.

Websites:

Research Projects:

Selected Publications:

Nde-1 mediated suppression of ciliogenesis affects cell cycle re-entry.
2011    Kim S., Zaghloul NA., Bubenshchikova E., Oh EC., Rankin S., Katsanis N., Obara T., and Tsiokas L.
Nature Cell Biology
Activation of TRPP2 through mDia1-dependent voltage gating.
2008    Bai CX., Kim S., Li WP., Streets AJ., Ong AC., and Tsiokas L.
EMBO Reports
Formation of a novel receptor-operated channel by heteromeric assembly of TRPP2 and TRPC1 subunits.
2008    Bai CX., Giamarchi A., Rodat-Despoix L., Padilla F., Downs T., Tsiokas L., and Delmas P.
EMBO Reports
Cell biology of Polycystin-2 (invited review).
2007    Tsiokas, L., Kim, S., and Ong, EC.
Cellular Signalling
PKD2 functions as an Epidermal Growth Factor-activated plasma membrane channel.
2005    Ma, R., Li, W. P., Rundle, D., Kong, J., Akbarali, H., and Tsiokas, L.
Molecular and Cellular Biology
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