Robert D. Foreman

Contact Information:
Robert D. Foreman


Foreman, Robert D. (HSC)

Department of:

College Of Medicine/Anesthesiology -Adjunct Professor
College Of Medicine/Physiology -George Lynn Cross Research Professor

Center of:

OK Center for Neurosciences -Member


University of Texas Medical Branch, Marine Biomedical Institute   Postdoctoral Fellowship   1975
Loyola University Chicago, Stritch School of Medicine, Department of Physiology   Ph.D. Physiology   1973
Central University of Iowa   B.A. Biology   1969

Professional Interest/Expertise/Specializations:
Pain affects more than 50 million Americans and is a frequent cause for people to visit a clinic. Approximately 45% of the population seeks medical help for pain at some point in their lives. Pain interferes with quality of life, sleep and productivity, and increases utilization of health care resources. Of the pain experiences, visceral disease and its referred pain is a prominent symptom in the clinical setting and one of the main reasons that patients seek medical care. Treatment of visceral pain resulting from visceral dysfunction is particularly challenging because it is seen by physicians in various specialties and little research has been done to address mechanisms. Furthermore, visceral pain does not often originate from a disease of a single internal organ but often results from concurrent algogenic conditions of more than one visceral source. The purpose of our research program is to study the neuro-humoral mechanisms of visceral dysfunction/pain and determine how neuromodulation can improve visceral function and reduce pain. The major research objectives are to: 1. Understand the role of the nervous system when pain and disease of one visceral organ such as the heart or colon affects the function and sensation in another visceral organ such as the gallbladder or urinary bladder; 2. Explain how neuromodulation (e.g. spinal cord stimulation) improves organ function and secondarily contributes to pain relief in an animal model of visceral disease.


Research Projects:

Selected Publications:

Comparison of changes in heart rate variability and sacral skin perfusion in response to postural changes in people with spinal cord injury.
2013    Jan YK, Anderson M, Soltani J, Burns S, Foreman RD
J. Rehabil Res Dev. 2013 Apr;50(2):203-14. PMID: 23761001
. Skin blood flow response to locally applied mechanical and thermal stresses in the diabetic foot.
2013    Jan YK, Shen S, Foreman RD, Ennis WJ.
Microvasc Res. 2013 Sep;89:40-6.
Differential effects of intravesical resiniferatoxin on excitability of bladder spinal neurons upon colon-bladder cross-sensitization
2013    Malykhina AP, Qin C, Lei Q, Pan XQ, Greenwood-Van Meerveld B, Foreman RD.
Brain Res. 2013 Jan 23;1491:213-24.
Activated cranial cervical cord neurons affect left ventricular infarct size and the potential for sudden cardiac death.
2012    Southerland EM, Gibbons DD, Smith SB, Sipe A, Williams CA, Beaumont E, Armour JA, Foreman RD, Ardell JL.
Auton Neurosci. 2012 Jul 2;169(1):34-42. Epub 2012 Apr 11. PMID: 22502863
Is constant current or constant voltage spinal cord stimulation superior for the suppression of nociceptive visceral and somatic stimuli? A rat model.
2012    Qin C, Martinez M, Tang R, Huynh J, Goodman Keiser M, Farber JP, Carman JC, Wienecke GM, Niederauer G, Foreman RD.
Neuromodulation. 2012 Mar-Apr;15(2):132-42; Epub 2012 Feb 24. PMID: 22364336
Neural mechanisms of spinal cord stimulation.
2012    Foreman RD, Linderoth B.
Int Rev Neurobiol. 2012;107:87-119.
Local cooling reduces skin ischemia under surface pressure in rats: an assessment by wavelet analysis of laser Doppler blood flow oscillations.
2012    Jan YK, Lee B, Liao F, Foreman RD.
Physiol Meas. 2012 Oct;33(10):1733-45
Diabetic rats show reduced cardiac-somatic reflex evoked by intrapericardial capsaicin.
2011    Liu XH, Qin C, Du JQ, Xu Y, Sun N, Tang JS, Li Q, Foreman RD.
Eur J Pharmacol.
Characterization of upper thoracic spinal neurons receiving noxious cardiac and/or somatic inputs in diabetic rats.
2011    Ghorbani ML, Qin C, Wu M, Farber JP, Sheykhzade M, Fjalland B, Nyborg NC, Foreman RD.
Auton Neurosci.
Spinal cord processing of cardiac nociception: are there sex differences between male and proestrous female rats?
2011    Little JM, Qin C, Farber JP, Foreman RD.
Brain Res.
Somatic afferent modulation of thoracic (T9-T10) spinal neurons receiving gastric mechanical input in rats.
2010    Qin, C, Chen JDC, Zhang J, Foreman RD.
Neuromodulation: Technology at the Interface.
Effect of Wheelchair Tilt-in-space and Recline Angles on Skin Perfusion over the Ischial Tuberosity in People with Spinal Cord Injury.
2010    Jan YK, Jones MA Rabadi MH Foreman RD Thiessen A.
Archives of Physical Medicine and Rehabilitation Arch Phys Med Rehabil.
Upper thoracic postsynaptic dorsal column neurons conduct cardiac mechanoreceptive information, but not cardiac chemical nociception in rats.
2010    Goodman Keiser MD, Qin C, Thompson AM, Foreman RD.
Brain Res.
Comparison of activity characteristics of the cuneate nucleus and thoracic spinal neurons receiving noxious cardiac and/or somatic inputs in rats.
2010    Qin C, Goodman MD, Little JM, Farber JP, Foreman RD.
Brain Res.
Cross-organ sensitization of thoracic spinal neurons receiving noxious cardiac input in rats with gastroesophageal reflux.
2010    Qin C, Malykhina AP, Thompson AM, Farber JP, Foreman RD.
Am J Physiol Gastrointest Liver Physiol.
Effects of spinal cord stimulation with "standard clinical" and higher frequencies on peripheral blood flow in rats.
2010    Gao J, Wu M, Li L, Qin C, Farber JP, Linderoth B, Foreman RD.
Brain Res.
Modulation of neuronal activity in dorsal column nuclei by upper cervical spinal cord stimulation in rats.
2009    Qin C, Yang X, Wu M, Farber JP, Linderoth B, Foreman RD.
Mineralocorticoid and glucocorticoid receptors in the amygdala regulate distinct responses to colorectal distension.
2009    Venkova K, Foreman RD, Greenwood-Van Meerveld B.
Characterization of upper thoracic spinal neurons responding to esophageal distension in diabetic rats.
2009    Qin C, Ghorbani ML, Wu M, Farber JP, Ma J, Foreman RD.
Auton Neurosci.
Bradykinin is involved in the mediation of cardiac nociception during ischemia through upper thoracic spinal neurons.
2009    Qin C, Du JQ, Tang JS, Foreman RD.
Curr Neurovasc Res.
Wavelet Analysis of Sacral Skin Blood Flow Oscillations to Assess Soft Tissue Viability in Older Adults.
2009    Jan YK, Struck BD, Foreman RD, Robinson C.
Microvasc Res.
Comparison of burst and tonic spinal cord stimulation on spinal neural processing in an animal model.
   Tang R, Martinez M, Goodman-Keiser M, Farber JP, Qin C, Foreman RD.
Neuromodulation (In Press, 2014)