Xin Zhang

Contact Information:
Xin Zhang


Zhang, Xin A. (Physiology-HSC)

Department of:

College Of Medicine/Physiology -Professor

Center of:

Peggy & Charles Stephenson Oklahoma Cancer Center -Member


Harvard Medical School, USA   Postdoctoral Research Associate   2000
University of Geneva, Switzerland   Ph.D.   1992
Tongji Medical University, China   M.S.   1988
Hubei Medical University, China   M.D.   1985

Professional Interest/Expertise/Specializations:
Cell adhesion and cell migration play important roles in variety of physiological and pathological events such as tissue morphogenesis, blood vessel stability, and cancer invasion and metastasis. Integrin is a major family of cell-extracellular matrix adhesion proteins and is essential for both cell adhesiveness and cell motility, while immunoglobulin superfamily (IgSF) proteins typically engage cell-cell adhesion and also regulate cell movement. To understand the interplay of cell adhesion and cell motility, the research in our lab has focused on the roles of cell adhesion proteins and their associated proteins in tumor progression and metastasis, angiogenesis, and tumor-microenvironment interaction. The long-term goal of our lab is to delineate the molecular and cellular mechanisms of cell adhesion and cell migration in tumor progression such as metastatic colonization and in tissue morphogenesis such as angiogenesis by combining both in vitro and in vivo approaches through dissecting the molecular interactions between cell adhesion molecules and cell environments. We primarily study the tetraspanin proteins, which associate with integrins and IgSF proteins and form tetraspanin-enriched microdomains (TEMs). Tetraspanins belong to a large superfamily and play important roles in various biological functions such as immune response, sperm-egg fusion, viral infection, and neuronal development. Tetraspanins have been found in various species ranging from yeast to human, indicating ancient and essential roles of tetraspanins during the evolution. The molecular and cellular mechanisms by which tetraspanins regulate a variety of biological functions still remain not well understood.


Research Projects:

Selected Publications:

Tetraspanin CD151 maintains vascular stability by balancing the forces of cell adhesion and cytoskeletal tension.
2011    Zhang, F., J. E. Michaelson, S. Moshiach, N. Sachs, W. Zhao, Y. Sun, A. Sonnenberg, J. M. Lahti, H. Huang, and X. A. Zhang.
Differential and Overlapping Functions of the Membrane Phospholipid Binding and Palmitoylation of EWI2.
2011    , B., Y. H. Zhang, Richardson, M. M., J. S. Zhang, E. Rubinstein, and X. A. Zhang.
Biochem. J.
Targeting Cell Movement in Malignant and Cardiovascular Diseases.
2011    Zhang, X. A. and R. I. Mahato.
Advanced Drug Delivery Reviews
CD82 endocytosis and cholesterol-dependent reorganization of tetraspanin-enriched microdomains and lipid rafts.
2009    . Xu, C., Y. H. Zhang, T. Muthusamy, M. M. Richardson, L. Liu, B. Zhou, Y. Zheng, R. S. Ostrom, and X. A. Zhang
The Transmembrane Domain Interactions Are Needed for KAI1/CD82-mediated Suppression of Cancer Invasion and Metastasis.
2009    Bari, R., Y. H. Zhang, F. Zhang, N. X. Wang, C. S. Stipp, J. J. Zheng, and X. A. Zhang.
Am. J. Path.
Tetraspanins and vascular function.
2009    Zhang, F., J. P. Kotha, L. K. Jennings, and X. A. Zhang
Cardiovascular Res.
KAI1/CD82 Metastasis Suppressor.
2008    Zhang, X. A. and R. Bari
Encyclopedia of Cancer. 2nd Edition, edited by M. Schwab, Springer-Verlag.
Tetraspanin CD151 Promotes Cell Migration through Regulating Integrin Trafficking.
2007    Liu, L., B. He, W. M. Liu, D. Zhou, J. V. Cox, and X. A. Zhang.
J. Biol. Chem.
The palmitoylation of metastasis suppressor KAI1/CD82 is important for its motility- and invasiveness-inhibitory activities.
2004    Zhou, B., Liu, L., Reddivari, M., and X. A. Zhang
Cancer Res.
Requirement of p130CAS-Crk coupling in KAI1/CD82-mediated suppression of cell migration.
2003    Zhang, X. A., He, B., Zhou, B., and L. Liu
J. Biol. Chem.
Associates with the Metastasis Suppressor KAI1/CD82 and Inhibits the Migration of Prostate Cancer Cells.
2003    Zhang, X. A., W. S. Lane, S. Charrin, E. Rubinstein, and L. Liu
Cancer Res.
Function of the tetraspanin CD151-a6b1 integrin complex during cellular morphogenesis.
2002    Zhang, X. A., A. R. Kazarov, X. Yang, A. L. Bontrager, C. S. Stipp, and M. E. Hemler.
Mol. Biol. Cell.
Transmembrane 4 superfamily proteins associate with activated protein kinase C (PKC) and link PKC to specific ß1 integrins.
2001    Zhang, X. A., A. L. Bontrager and M. E. Hemler
J. Biol. Chem.
. Phosphorylation of a conserved integrin ¿3 chain QPSXXE motif regulates signaling, motility, and cytoskeletal engagement.
2001    Zhang, X. A., A. L. Bontrager, G. Bazzoni, S. -K. Kraeft, C. S. Stipp, L. B. Chen, and M. E. Hemler.
Mol. Biol. Cell.
Interaction of the integrin ß1 cytoplasmic domain with ICAP protein.
1999    Zhang, X. A. and M. E. Hemler.
J. Biol. Chem.
Isolation and characterization of a cyclic hydroxamic acid from a pollen extract, which inhibits cancerous cell growth.
1995    Zhang, X., Habib, F. K., Ross, M., Burger, U., Lewenstein, A., Rose, K., and Jaton, J. -C.
J. Med. Chem.