Kenneth J. Dormer

Contact Information:
Kenneth J. Dormer



 

Dormer, Kenneth J. (HSC)
Faculty

Department of:

College Of Medicine/Physiology -Professor
College Of Medicine/Psychiatry & Behavioral Scienc -Adjunct Professor

Center of:

OK Center for Neurosciences -Member

Other Organization:

Heart Rhythm Institute -Senior Scientist

Education:

Cornell University   MS   1969
UCLA   PhD   1974
University of Texas Medical Branch Galveston   NIH Post-doctoral Fellowship   1978

Professional Interest/Expertise/Specializations:
Two diverse interest areas of research: auditory physiology and cardiovascular physiology have been applied using magnetic targeted therapy of nanoparticles containing therapeutic payloads. These applications of physiology are sought to be translated into the clinic. Previously, auditory studies in collaboration with the Hough Ear Institute, Oklahoma City, which I co-founded with Jack Hough, MD and where I served in research and administrative roles during that collaboration, we co-developed portions of the cochlear implant, the Audiant Bone Conductor and the SOUNDTEC middle ear implantable device. All three devices were approved by the FDA for use in patients. Most recently, our collaboration led to the delivery of therapeutics to the inner ear (cochlea) using magnetic nanoparticles, pulled across the round window membrane in efforts to prevent hearing loss (deafness) from noise or toxin-induced cochlear injury. These efforts led to the formation of SOUNDTEC Inc., of Oklahoma City, through which the device was marketed. Previously, Dormer had co-founded NanoBioMagnetics Inc. in Edmond, OK. Most recently, Dormer co-founded NanoMed Targeting Systems Inc., Oklahoma City, in collaboration with an Israeli electromagnetics company. Cardiac studies previously focused on the neural control of the cardiovascular system, emanating from the medulla of the brain. Using dog models, we described this cardiovascular control region essential for life and involved in disease states such as hypertension. Presently, in collaboration with the Heart Rhythm Institute, Division of Cardiology, Department of Medicine, we are collaborating on targeting the integrative ganglionated plexi (GP) of the intrinsic cardiac nervous system. We are targeting magnetic nanoparticles that convey a therapeutic payload to GP only (targeted therapy) for the prevention of atrial fibrillation, the most common cardiac arrhythmia in the world.

Websites:

Research Projects:

Selected Publications:

Incorporation, release and effectiveness of Dexamethasone in poly(lactic-co-glycolic acid) nanoparticles for inner ear drug delivery.
2011    Wang Y, Gao X, Chen K, Grady B, Dormer K, Kopke R.
J Nanotechnology in Engineering & Medicine
Magnetic assisted transport of PLGA nanoparticles through a human round window membrane model.
2010    Guo X, Wang Y, Chen K, Grady B, Dormer K and Kopke RD.
J. Nanotechnol Eng Med
A two-magnetic system to push therapeutic nanoparticles.
2010    Shapiro B, Dormer K, and Rutel I.
Journ. Magnetics & Magnetic Materials Published Proceedings 8th International Conference on the Scientific and Clinical Applications of Magnetic Carriers
Autonomic denervation using magnetic nanoparticles.
2010    Yu L, B. Scherlag, K. Dormer, K. Nguyen, C. Pope, KM. Fung and S. Po.
Circulation
Magnetically targeted, Technetium99m labeled Nanoparticles to the Inner Ear.
2008    Dormer KJ, Awasti V, Galbraith W,, Kopke RD, Chen K, and Wassel R.
J. Biomedical Nanotechnology
Distribution of PLGA nanoparticles in chinchilla cochleae.
2007    Ge X, Jackson RL, Liu J, Harper EA, Hoffer ME, Wassel RA, Dormer KJ, Kopke RD, Balough BJ.
Otolaryngol Head Neck Surg.
Magnetic Characterization of Superparamagnetic Nanoparticles Pulled Through Model Membranes.
2007    Barnes, AL, Wassel RA, Mondalek F, Chen K, Kopke R, Dormer KJ,
J. Biomagnetic Research & Technology
Dispersion of superparamagnetic iron oxide nanoparticles in poly(D,L-lactide-co-glycolide) microparticles.
2007    Wassel RA, Brady B, Kopke RD and Dormer KJ
Surfaces and Colloids A: Physicochemical Engineering Aspects
A novel model of the round window membrane in magnetic targeted delivery.
2006    Mondalek FG, Zhang YY, Kopke R, Kropp B and Dormer KJ
Nanobiotechnology
Magnetic nanoparticles: Inner ear targeted molecule delivery and middle ear implant.
2006    Kopke RD, Wassel RA, Mondalek F, Grady B, Chen K, Liu J, Gibson D and Dormer KJ
Audiology & Neurotolog
MRI compatibility and safety of the SOUNDTEC Direct System.
2006    Dyer K, Nakmali D, and Dormer KJ:
Laryngoscope
Internalization of nanoparticles in middle ear epithelium and response to external magnetic field. Biomaterials
2004    Dormer KJ, Seeney CE, Lewelling K, Lian G, Gibson D, and Johnson M
Biomaterials
Human middle ear transfer function measured by double laser interferometry system.
2004    Gan RZ, Wood MW and Dormer KJ
Otology & Neurotology
Computer integrated finite element modeling of human middle ear. Biomechanics and Modeling in Mechanobiology.
2002    Sun Q, Gan RZ, Chang K-H, and Dormer KJ
Biomechanics and Modeling in Mechanobiology
An Advanced Computer-Aided Geometric Modeling and Fabrication Method for Human Middle Ear.
2002    Sun Q, Chang KH, Dormer KJ, Dyer RK, and Gan RZ
Medical Engineering & Physics
Finite element modeling and human temporal bone studies in middle ear mechanics.
2002    Gan RZ, Sun QL, Wood MW and Dormer KJ
Ann. Biomed. Engineering
Three Dimensional Modeling of Middle Ear Biomechanics and its Applications.
2002    Gan RZ, Sun Q, Dyer RK, Chang K-H and Dormer KJ
Otology & Neurotology
Biomechanical Influences of magnetic resonance imaging on the SOUNDTEC Direct SystemTM Implant.
2002    Dyer RK, Dormer KJ, Hough JVD, Nakmali U and Wickersham R:
Otol. Head & Neck Surg
Mass loading on ossicles and middle ear function.
2001    Gan RZ, Dyer RK, Wood MW and Dormer KJ
Ann. Otol. Rhin. Laryngol
The Hearing Laser Vibrometer Initial Clinical Results.
2000    Dyer RK, Dormer KJ, Pineda M, Conley K, Saunders J and Dennis M
The Function and Mechanics of Normal, Diseased and Reconstructed Middle Ears. Eds. Rosowski JJ and Merchant SN. Kugler Publications, The Hague, The Netherlands
Cochlear implantation in children.
2000    Dormer KJ and Whaley PA
Ethics & Medicine.
Residual hearing is not affected by middle ear implantable hearing device in the bovine model.
1999    Dormer KJ, Dennis M, Baker RS and Katz B
Am. J. Otology
Middle ear mechanics, finite element modeling and human temporal bone studies
1999    Gan RZ, Sun Q, Wood MW, Chang KH and Dormer KJ
Proc. 1999 Bioengineering Conf., (Goal VK, Spilker RL, Ateshian Gaand Soslowsky LJ (eds)
Research and development in developing countries.
1999    Dormer KJ and Kinoti G
Perspectives on Science and Christian Faith.
Implantable hearing device performance measured by laser Doppler interferometry.
1997    Gan RZ, Wood MW, Ball GR, Dietz TG and Dormer KJ
ENT-Ear, Nose & Throat J.
Effects of magnetic resonance imaging on implantable permanent magnets.
1995    Schneider ML, Walker GB, Dormer KJ
Am. J. Otol.
The Audiant Bone ConductorTM: An update of North American patients.
1994    Hough JH, Wilson N, Dormer KJ, and Rohrer M
Am. J. Otol.
The cardiovascular effects of ricin in rabbits.
1994    Christianson VJ, Hsu CH, Dormer KJ and Robinson CP
Pharmacology and Toxicology
Pressor and endocrine responses to lesions of canine rostral ventrolateral medulla.
1994    Stith RD and Dormer KJ
Am. J. Physiol
Organization of presumptive catecholamine-synthesizing neurons in the canine medulla oblongata.
1993    Dormer KJ, Anwar M, Ashlock SR and Ruggiero DA
Brain Res.