Chung, Kyung W. (HSC)
Professor and Vice Chairman
University of Oklahoma
Various aspects of reproductive endocrinology and neuroendocrinology, including drug, vitamin and heavy metal-induced alteration of endocrine and neuroendocrine cell functions, androgen synthesis and metabolism, and steroid and protein hormone receptors. Our research is directed at understanding the mechanism(s) by which drugs, vitamins and toxic chemicals have deleterious effects on the testicular functions and steroidogenesis; alter the pituitary gonadotropin releasing hormone (GnRH) receptor contents, changing the magnitude and frequency of episodic secretion of pituitary gonadotropins; alters the hypothalamic GnRH content and hypophysial portal secretion of GnRH, impairing the normal pituitary function in terms of gonadotropin secretion, and changes the amount of neurotransmitters in the brain, modifying episodic pattern of hypothalamic GnRH and/or pituitary gonadotropin secretion.
Other project is being investigated molecular mechanism(s) involved in the pathogenesis of testicular feminization syndrome. We hope to find defect(s) in the structure of the gene encoding the androgen receptor in androgen insensitive rats. The localization and quantitation of androgen receptor mRNA were examined by in situ hybridization and RNA blot analyses. Much stronger signal indicating the presence of androgen receptor mRNA was observed in the tfm testis than in the normal. Analysis of poly (A)+ RNA by Northern blot hybridization using 32P-labeled androgen receptor cDNA probe revealed a 10-Kb mRNA band. The relative androgen receptor mRNA levels quantitated by a laser scanning densitometry were increased in tfm rats when compared to those of normal controls, indicating that in tfm rats transcription of androgen receptor mRNA is increased but translation of androgen receptor protein is defective. We have been focusing on determination of mutation sites by comparing tfm rat androgen receptor cDNA sequence with that of normal control rats.
Functional anatomy of the thumb sagittal band.
Jaibaji, M. Rayan, G.M. and Chung, K.W.
J. of Hand Surgery
Temas Clave Anatomia (Spanish Version of Gross Anatomy), 6th edition
Chung, K.W. and Chung, H.M.
Lippincott Williams & Wilkins
Gross Anatomy, Board Review Series, 6th edition
Chung, K.W. and Chung, H. M.
Lippincott Williams & Wilkins Co.